Processes for preparing cholesta-1,5,7-trien-3-ol

Details Processes for preparing cholesta-1,5,7-trien-3-ol Processes for preparing cholesta-1,5,7-trien-3-ol

1987-01-30

1988-02-02

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Oxygen containing

C07C 3542

Patent

active

047230452

ABSTRACT:
New processes for preparing cholesta-1,5,7-trien-3-ol which is a key intermediate in the synthesis of 1.alpha.-hydroxyvitamin D.sub.3. The processes utilize the steps of reacting cholesta-1,4,6-trien-3-one with isopropenyl acetate in the presence of an acid catalyst followed by reduction of the resultant cholesta-1,3,5,7-tetraen-3-yl-acetate.

REFERENCES:
Turner et al., "J. Chem. Soc". (1969) p. 2568.
Romo et al., "J. Org. Che.", (1950) vol. 15, p. 896.
Woodward et al., "J. Amer. Chem. Soc.", vol. 74, No. 17 pp. 4223+ (1952).
Kaneko et al., "Tetrahedron" vol. 30, p. 2701 (1974).
Guest et al., "J. Chem. Soc. " Parkin I (1979) p. 1695.

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