Processes for preparing bis-naphthalimides containing amino-acid

Details Processes for preparing bis-naphthalimides containing amino-acid Processes for preparing bis-naphthalimides containing amino-acid

1994-05-26

1995-10-24

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Amino nitrogen containing

560158, 564138, 564141, C07C20950

Patent

active

054611768

ABSTRACT:
This invention relates to bis-naphthalimides, including 2,2'-[1,2-ethanediylbis[imino(1-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione] and 2,2'-[1,2-ethanediylbis[imino(2-methyl-2,1-ethanediyl)]]-bis[5-nitro-1H-be nz[de]isoquinoline-1,3(2H)-dione], processes for their preparation, pharmaceutical compositions containing them, and methods of using them to treat cancer in mammals.

REFERENCES:
patent: 4874863 (1989-10-01), Brana et al.
patent: 5086059 (1992-02-01), Ardecky et al.
patent: 5206249 (1993-04-01), Sun
patent: 5329048 (1994-07-01), Sun
Muir et al., Synth. React. Inorg. Met.-Org. Chem., vol. 11, No. 4 (1981) pp. 317-331.
Asperger et al., Inorganic Chemistry, vol. 4, No. 10 (1965) pp. 1395-1397.

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