Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...
Patent
1997-10-08
1999-01-05
Ford, John M.
Organic compounds -- part of the class 532-570 series
Organic compounds
Unsubstituted hydrocarbyl chain between the ring and the -c-...
546 16, 546221, 546243, 540453, 540463, 540528, C07D22310, C07D22502, C07D21176
Patent
active
058564764
ABSTRACT:
Processes are disclosed for preparing the azepine intermediates of the formula ##STR1## These intermediates can be reacted with acylmercaptocarboxylic acids of the formula ##STR2## to give the pharmaceutically active products.
REFERENCES:
patent: 4105776 (1978-08-01), Ondetti et al.
patent: 4192945 (1980-03-01), Ondetti
patent: 4339600 (1982-07-01), Ondetti et al.
patent: 4374829 (1983-02-01), Harris et al.
patent: 4409146 (1983-10-01), Thorsett
patent: 4410520 (1983-10-01), Watthey
patent: 4415496 (1983-11-01), Harris et al.
patent: 4460579 (1984-07-01), Karanewsky
patent: 4465679 (1984-08-01), Huang et al.
patent: 4470988 (1984-09-01), Watthey
patent: 4473575 (1984-09-01), Watthey
patent: 4474778 (1984-10-01), Gordon et al.
patent: 4477464 (1984-10-01), Slade et al.
patent: 4512924 (1985-04-01), Attwood et al.
patent: 4533661 (1985-08-01), Karanewsky
patent: 4537885 (1985-08-01), Watthey
patent: 4539150 (1985-09-01), Katakami et al.
patent: 4548932 (1985-10-01), Sugihara et al.
patent: 4575503 (1986-03-01), Watthey
patent: 4584294 (1986-04-01), Ruyle
patent: 4587050 (1986-05-01), Harris et al.
patent: 4587238 (1986-05-01), Harris et al.
patent: 4594341 (1986-06-01), Cheung et al.
patent: 4617301 (1986-10-01), Patchett et al.
patent: 4629787 (1986-12-01), Harris et al.
patent: 4699905 (1987-10-01), Yangisawa et al.
patent: 4711884 (1987-12-01), Karanewsky
patent: 4734410 (1988-03-01), Yanagisawa et al.
patent: 4749688 (1988-06-01), Haslanger
patent: 4824832 (1989-04-01), Flynn et al.
patent: 4873235 (1989-10-01), Parsons et al.
patent: 4963539 (1990-10-01), Delaney
patent: 4973585 (1990-11-01), Flynn et al.
patent: 5098934 (1992-03-01), Vevert et al.
patent: 5190974 (1993-03-01), Clemence et al.
patent: 5208236 (1993-05-01), Neustadt
patent: 5225401 (1993-07-01), Seymour
patent: 5232920 (1993-08-01), Neustadt
patent: 5233516 (1993-08-01), Delaney
patent: 5238924 (1993-08-01), Smith
patent: 5262436 (1993-11-01), Haslanger et al.
patent: 5362727 (1994-11-01), Robl
patent: 5366973 (1994-11-01), Flynn et al.
Watthey et al., J. Med. Chem. 28, pp. 1511-1516 (1985).
Slade et al., J. Med. Chem. 28, pp. 1517-1521 (1985).
Thorsett et al., J. Med. Chem. 29 pp. 251-260 (1986).
Yanagisawa et al., J. Med. Chem., 30, pp. 1984-1991 (1987).
Yanagisawa et al., J. Med. Chem. 31 pp. 422-428 (1988).
Parsons et al., Biochem and Biophysical Research Comm. 117 pp. 108-113 (1993).
Atwood et al., FEBS Letters, Vol. 165, pp. 201-206 (1984).
Natoff et al., Drugs of the Future, vol. 12, pp. 475-483 (1987).
Itoh et al., Chem. Pharm. Bull., vol. 34, pp. 1128-1147 and 2078-2089 (1986).
Flynn, Tetrahedron Letters, vol. 31, pp. 815-818 (1990).
Thorsett, Actual Chim. Ther., vol. 13, pp. 257-268 (1986).
Atwood et al., J. Chem. Soc. Perkin Trans I (1986) pp. 1011-1029.
Robl Tetrahedron Letters, vol. 35 pp. 393-396 and 1393-1396, (1994).
Delaney et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1783-1788 (1994).
Robl et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 1789-1794 (1994).
Robl et al., Bioorganic & Medicinal Chemisty Letters, vol. 4 pp. 2055-2060 (1994).
Das et al., Bioorganic & Medicinal Chemistry Letters, vol. 4, pp. 2193-2198 (1994).
Bolos et al., J. Org. Chem., 57 3535-3539 (1992).
Bolos et al., Tetrahedron, vol. 48, pp. 9567-9576 (1992).
Adams et al. Synthetic Communications, vol. 18, 2225-2231 (1988).
Chackalamannil et al., Bioorganic & Medicinal Chemistry Letters, vol. 2, pp. 1003-1006 (1992).
Flynn et al., J. Med. Chem., 36 pp. 2420-2423 (1993).
Robl et al., J. Am. Chem. Soc., 116 pp. 2348-2355 (1994).
Robl. et al. Bioorg. Med. Chem. Lett., 4, 1795-1800 (1994).
Dussaule et al., Jour. of Clinical Endocrinology and Metabolism, vol. 72, pp. 653-659, 1991.
Loffi et al., Gastroenterology, vol. 96, pp. 167-177, 1989.
Fyhrquist et al., The Lancet Dec. 21/28, 1985, p. 1439.
Fernandez Cruz, The Lancet, Dec 21/28, 1985, pp. 1439-1400.
Greene et al., Protective Groups In Organics Synthesis (John Wiley & Sons, NY) pp. 224-231 (1991).
Davis Stephen B.
E. R. Squibbs & Sons, Inc.
Ford John M.
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