Processes for preparing a substituted gamma-amino acid

Details Processes for preparing a substituted gamma-amino acid Processes for preparing a substituted gamma-amino acid

2008-11-25

2011-12-06

Zucker, Paul A (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

Reexamination Certificate

active

08071808

ABSTRACT:
The present invention is related to processes suitable for industrial synthesis of pregabalin from (R)-(−)-3-(carbamoylmethyl)-5-methylhexanoic using sodium hypochlorite as described herein. In addition, the present invention is related to pregabalin which is substantially free of impurities and pharmaceutical compositions comprising pregabalin.

REFERENCES:
patent: WO 96/38405 (1996-12-01), None
patent: WO 2006/122255 (2006-11-01), None
Hoekstra, Marvin et al., “Chemical Development of CI-1008, an Enantiomerically Pure Anticonvulsant,”Organic Process, Research&Development, vol. 1, No. 1, Jan. 1, 1997, pp. 26-38.

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