Processes for preparing 7-carboxy substituted steroids

Details Processes for preparing 7-carboxy substituted steroids Processes for preparing 7-carboxy substituted steroids

2007-03-27

2007-03-27

Owens, Amelia A. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C549S330000

Reexamination Certificate

active

10392956

ABSTRACT:
This invention relates to processes for the preparation of 7-carboxy substituted steroid compounds of Formula I,wherein R1is selected from H or COR4;R4is C1–C6alkyl or C1–C6alkoxy;R3is C1–C6alkyl;Z1is —CH2— or wherein O—COR4is in the α configuration;Z2is —CH—;or Z1and Z2may be taken together to form a carbon-carbon double bond;Q isThese intermediates are useful in the preparation of 7-carboxy substituted steroid compounds, and particularly, the invention is directed to novel and advantageous methods for the preparation of 9,11-α-epoxy-17-α-hydroxy-3-oxopregn-4-ene-α-7-21-dicarboxylic acid, γ-lactone, methyl ester (eplerenone; epoxymexrenone).

REFERENCES:
patent: 3787396 (1974-01-01), Weier
patent: 4069219 (1978-01-01), Weier
patent: 4559332 (1985-12-01), Grob et al.
patent: 5237064 (1993-08-01), Bakshi et al.
patent: 5981744 (1999-11-01), Ng et al.
patent: WO 98/25948 (1998-06-01), None
Ali, H. et al.,J. Med. Chem.(1993), 36(21), 3061-3072.
Martin, J.C., et. al.,J. Amer. Chem. Soc., (1991), 113, 7277-7287.
Murahashi, Shun-ichi, “Palladium (o)-Catalyzed Carbonylation of Allyl Phosphates and Allyl-Acetates. Selective Synthesis of beta, gamma-Unsaturated Esters”Tetrahedron Letters, vol. 29, No. 39, 1988, 4945-4948.
Page, P. C.,Tetrahedron(1991), 47, 2871-2878.
Panda, J., et. al.,Tetrahedron Letters(1999), 40, 6693-6694.
Paquette, L. A., et. al.,J. Am. Chem. Soc.(1995), 117(4), 1455-6.
Pollack, et. al.,J. Amer. Chem. Soc., 1987, 109, 5048-5050.
Rehnberg, N., et. al.,J. Org. Chem.(1990), 55(14), 4340-9.
Schwede, W. et. Al.,Steroids(1998), 63(3), 166-177.
Tomioka, K., et. al.,J. Org. Chem.(1988), 53(17), 4094-4098.
Tsubuki, et. al.,J. Org. Chem., 1992, 57, 2930-2934.
Turuta, A. M. et. Al., Mendeleev Commun. (1992), 47-8.
Uchiyama, M., et. al.,Tetrahedron Letters(2000), 41(51), 10013-10017.
Vanderiei, J. M. de L.,Synthetic Communications(1998), 28(16), 3047-3055.
Waldemar, A., et. al.,Chem. Rev., (2001), 101, 3499-3548.
Zeng, et. al.,J. Amer. Chem. Soc., 1991, 113, 3838-3842.

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