Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny

Details Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny

1995-01-17

1995-08-29

McKane, Joseph K.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D25702

Patent

active

054461219

ABSTRACT:
The present invention relates to processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxyli c acid and to intermediates useful in such processes. The present invention also relates to a process for deprotecting compounds containing a protected 2H-tetrazolyl group, which process comprises reacting a the protected compound with a Lewis acid in the presence of a thiol.

REFERENCES:
patent: 4333943 (1982-06-01), Kurchacova et al.
patent: 4880804 (1989-11-01), Cavini et al.
patent: 5015651 (1991-05-01), Cavini et al.
patent: 5053329 (1991-10-01), Chen et al.
patent: 5093346 (1992-03-01), Carini et al.
patent: 5124335 (1992-06-01), Patchett et al.
patent: 5212195 (1993-05-01), Clark et al.
patent: 5380739 (1995-01-01), Clark et al.
Hypertension, Hypotensive Action . . . Rats., Wong et al., pp. 459-468, vol. 15, 1990.
Biochemical and Biophysical Research Communications, Identification . . . Subtypes, Chiu et al., pp. 196-203, 1989.
J. Pharmacology and Experimental Therapeutics, vol. 256, Pharmacodynamic . . . Activity, Vaupel et al., pp. 211-221, 1990.
CA119:139239d Substituted . . . antagonists, Clark et al., p. 882, 1993.
CA120:270407v Preparation . . . antagonists. Fisher et al., pp. 1071-1072, 1994.
Carini, D. J., "Nonpeptide Anglotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl) imidazoles as Potent, Orally Active Antihypertensives", J. Med. Chem. (1991), vol. 34, No. 8, pp. 2525-2547.

Affiliated with

Also associated with

Rating

Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-1820083