Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny

Details Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny Processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl) bipheny

1994-05-27

1995-05-02

Lee, Mary C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D25704

Patent

active

054121027

ABSTRACT:
The present invention relates to processes for preparing 1-butyl-2-[2'-(2H-tetrazol-5-yl)biphenyl-4-ylmethyl]-1H-indole-3-carboxyli c acid and to intermediates useful in such processes. The present invention also relates to a process for deprotecting compounds containing a protected 2H-tetrazolyl group, which process comprises reacting a the protected compound with a Lewis acid in the presence of a thiol.

REFERENCES:
patent: 5093346 (1992-03-01), Carini et al.
patent: 5124335 (1992-06-01), Patchett et al.
patent: 5212195 (1993-05-01), Clark et al.
Carini, D. J., et al., "Nonpeptide Angiotensin II Receptor Antagonists: The Discovery of a Series of N-(Biphenylylmethyl) imidazoles as Potent, Orally Active Antihypertensives", J. Med. Chem. (1991), vol. 34, No. 8, pp. 2525-2547.

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