Processes for preparation of solid, rapidly released medicament

Details Processes for preparation of solid, rapidly released medicament Processes for preparation of solid, rapidly released medicament

1988-09-20

1990-01-09

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Lymphokine

514356, A61K 3178, A61K 3144

Patent

active

048927309

ABSTRACT:
Solid dihydropyridines, e.g. nifedipine and nimodipine preparations having a maximum standard deviation of the active compound content of 3% contain 1 part by weight of nifedipine, 2 to 6 parts by weight of PVP with a mean molecular weight of 15,000 to 50,000, 3.5 to 15 parts by weight of cellulose, 0.25 to 4 parts by weight of starch and 0.5 to 4 parts by weight of cross-linked insoluble PVPP, and, if appropriate, one or more further pharmaceutical auxiliaries and excipients. These preparations show a good release of dihydropyridine with good content uniformity.

REFERENCES:
patent: 4216155 (1980-08-01), Haas et al.
patent: 4412986 (1983-11-01), Kawata et al.
Chemical Abstracts; vol. 83 (1975) #209407w; Kramer et al.
Chemical Abstracts; vol. 90 (1979) #109,987m; Kawata et al.

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