Processes for preparation of N-protected-β-amino...

Details Processes for preparation of N-protected-β-amino... Processes for preparation of N-protected-β-amino...

2006-10-17

2006-10-17

Page, Thurman K. (Department: 1621)

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

Reexamination Certificate

active

07122696

ABSTRACT:
Herein are disclosed a process for increasing in purity, or purifying, an N-protected-β-aminoalcohol which process comprises (i) adding water to a polar organic solvent in which an N-protected-β-aminoalcohol such as a (2R,3S)- or (2S,3R)-3-tert-butoxycarbonylamino-1-halo-2-hydroxy-4-phenylbutane or the like, or (ii) crystallizing such an N-protected-β-aminoalcohol from a diol or a diol-based mixed solvent, and a process for producing the corresponding N-protected-β-aminoepoxide which process comprises treating, with a base, the thus purity-enhanced N-protected-β-aminoalcohol. Such N-protected-β-aminoalcohols and N-protected-β-aminoepoxides are both useful as synthetic intermediates for medicine compounds, such as, e.g., HIV protease inhibitor and the like.

REFERENCES:
patent: 6605732 (2003-08-01), Malik et al.
patent: 2 325 919 (2000-08-01), None
patent: 0691 345 (1996-01-01), None
patent: 703209 (1996-03-01), None
patent: 774453 (1997-05-01), None
patent: 0 827 943 (1998-03-01), None
patent: 969000 (2000-01-01), None
patent: 1 050 532 (2000-11-01), None
patent: 1 052 257 (2000-11-01), None
patent: 2000-319235 (2000-11-01), None
patent: 2001-39940 (2001-02-01), None
patent: 00/43357 (2000-07-01), None

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