Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2006-09-26
2006-09-26
Badio, Barbara P. (Department: 1617)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C540S044000
Reexamination Certificate
active
07112669
ABSTRACT:
Intermediates in the preparation of 9,11-epoxy steroids are disclosed. Particularly, disclosed are 11,12-epoxy steroid, 4,5-9,11-diepoxy steroid and 12-keto steroid intermediates.
REFERENCES:
patent: 3053856 (1962-09-01), Payne et al.
patent: 3200113 (1965-08-01), Christiansen et al.
patent: 3300489 (1967-01-01), Holden et al.
patent: 3413288 (1968-11-01), Creger et al.
patent: 3759791 (1973-09-01), Marsheck et al.
patent: 3879417 (1975-04-01), Wamant et al.
patent: 3972871 (1976-08-01), Karim et al.
patent: 3972878 (1976-08-01), Schirmann et al.
patent: 4118488 (1978-10-01), Philippson et al.
patent: 4270994 (1981-06-01), Behling
patent: 4559332 (1985-12-01), Grob et al.
patent: 5565588 (1996-10-01), Batist et al.
patent: 5616742 (1997-04-01), Fu et al.
patent: 2404947 (1974-08-01), None
patent: 2443746 (1976-10-01), None
patent: 2349022 (1977-05-01), None
patent: 2932925 (1981-05-01), None
patent: 123 734 (1984-11-01), None
patent: 122 232 (1985-12-01), None
patent: 165 902 (1987-02-01), None
patent: WO 97/21720 (1997-06-01), None
Abstract 084228, “Hydroxylated Androstane Production From Sterols”, Chemical Abstracts, vol. 100, No. 11, p. 430, Mar. 12, 1984 and JP 58 179 498 A (Danippon Ink and Chemicals, Inc.); Japan, Oct. 20, 1983.
Arias et al., “Epoxidation of Alkenes With Trichloroacetonitrile/Hydrogen Peroxide In a Neutral Biphasic Solvent System”,J. Org. Chem., vol. 48, pp. 888-890, 1983.
Brown et al., “Steroidal Aldosterone Blockers VII”,J. Med. Chem., vol. 6, pp. 732-735, 1963.
Brown et al., “Steroidal Aldosterone Blockers III”,J. Org. Chem., vol. 25, No. 1, pp. 96-99, 1960.
Carruthers et al., “Synthesis Of Corticoids From 9α-Hydroxyandrost-4-ene8,17-dione”,J. Org. Chem., vol. 57, pp. 961-965, 1992.
Christiansen et al., “The Reaction Of Steroidal 4,6-dien-3-ones With Cyanide”, Steroids, vol. 1, No. 6, pp. 620-627, Jun. 1963.
Database WPI, Section Ch, Week 8145, Derwent Publications, Ltd., London, GB; AN 81-82258D and JP 56 120 697 A (Mitsubishi Chem. Ind. Ltd.), Sep. 22, 1981.
Degasparo et al., “Antialdosterones: Incidence And Prevention Of Sexual Side Effects”,J. Steroid Biochem, vol. 32, No. 13, pp. 223-227, 1989.
Degasparo et al., “Three New Epoxy-Spirolactone Derivatives: Characterizationin Vivoandin Vitro”, The Journal Of Pharmacology And Experimental Therapeutics, vol. 240, No. 2, pp. 650-656, 1987.
Deshayes, “Utilisation De Modéles Mathématiques Pour 1'optimisation En Fermentation. Applicatoins Aux Transfor-mations Par Les Micro-organismes”, Bulletine De La Societe Chimque De France 2 Partie—Chimie Organique, Biochimie, No. 1-2, pp. 24-34, May 18, 1979 (translation).
Gabriel, S., “Condensationsproducte aus Phtalsaureanhydrid”,Ber., pp. 1389-1396, 1884.
Grob et al., “Steroidal, Aldosterone Antagonists. Increased Selectivity of 9α, 11-Epoxy Derivatives”,Helvetica Chimica Acta, vol. 80, No. 2, pp. 566-585, Mar. 24, 1997.
Hellberg et al., “5α-Hydroxy-3α-Cholestanecarboxylic Lactone”,OPPI Briefs, vol. 15, No. 3, pp. 154-156, 1983.
Nagata et al., “Angular-Substituted Polycyclic Compounds. I. Cyanation Of Δ-Cholesten-3-one”,Journal of Organic Chemistry, vol. 26, pp. 2413-2420, 1961.
Nagata et al., “Hydrocyanation, VI. Application Of The New Hydrocyanation Methods To Conjugate Hydrocyanation Of α,β-Unsaturated Ketones, Conjugated Dienones, And Conjugated Enamines And To Preparation Of α-Cyanohydrins”,J. Amer. Chem. Soc., vol. 94:13, pp. 4654-4672, 1972.
Nickisch et al., “Aldosterone Antagonists.3.Synthesis and Activities of Steroidal 7α-(Alkoxycarbonyl)-15,16-Methylene Methylene Spirolactones”,Journal of Medicinal Chemistry, vol. 33, No. 2, pp. 509-513, Feb. 1990.
Ogata et al., “The Alkali Phosphate-Catalyzed Epoxidation And Oxidation By A Mixture Of Nitrile And Hydrogen Peroxide”, Tetrahedron, vol. 20, pp. 2065-2068, 1964.
Ogata, “The Kinetics Of The Phosphate/Catalyzed Epoxidation Of Styrenes With A Mixture Of Nitrile & Hydrogen Peroxide”, Bull. Chem. Soc. Of Japan, vol. 38, No. 2, pp. 194-199, 1965.
Payne et al., “Reactions of Hydrogen Peroxide. VII. Alkali-Catalyzed Epoxidation and Oxidation Using A Nitrile As Co-reactant”,J. Org. Chem., vol. 26, pp. 659-663, 1961.
Peterson et al., “Microbiological Transformations of Steroids. VI. Preparation of 11α-Hydroxy-6-dehydroproges-terone”, Journal Of The American Chemical Society, vol. 75, No. 2, pp. 419-421, Jan. 29, 1953.
Turner et al., “Applications Of High-potential Quinones. Part I. The Mechanism Of Dehydrogenation Of Steroidal Ketones By 2,3 Dichloro-5,6-dicyanobenzoquinone”,J. Chem. Soc., pp. 1720-1730, 1967.
Van Leusen et al., “Chemistry of Sulfonylmethyl Isocya-nides. 33. Synthesis of 17-(isocyanotosylmethylene) Steroids: Precursors To Pregnane Derivatives” Recueil Des Travaux Chimiques Des Pays-Bas, vol. 110, No. 10, pp. 393-401, Oct. 1991.
Weir et al., “7α-Carboalkoxy Steroidal Spirolactones As Aldosterone Antagonists”, Journal of Medicinal Chemistry, vol. 18, No. 8, pp. 817-821, Aug. 1975.
Anderson Dennis K.
Baez Julio A.
Erb Bernhard
Kowar Thomas R.
Kunda Sastry A.
Badio Barbara P.
Pharmacia Corporation (of Pfizer Inc.)
Thomas Robert S.
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