Processes for obtaining exoenzymes by culture

Details Processes for obtaining exoenzymes by culture Processes for obtaining exoenzymes by culture

1986-07-07

1990-05-22

Wiseman, Thomas G.

Chemistry: molecular biology and microbiology

Condition responsive control process

435183, 435202, 435222, 435813, 435818, C12Q 300, C12N 900, C12N 928, C12N 956

Patent

active

049277510

ABSTRACT:
Exoenzymes, such as proteases, xylanases and amylases, are obtained continuously by cultivation of exoenzyme-producing microorganisms in one step in a fermenter which is operated with continuous flow and in which a deficiency state corresponding to maximal enzyme productivity is effected. Optical density of the culture (as a measure of the biomass density) and exoenzyme concentration in culture can be monitored to control the timing and extent of the deficiency state. It is particularly advantageous to impose an oxygen limitation and to maintain the deficiency state continuously by exerting an effect on the oxygen input.

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Kjaergaard, Biotechnology Letters, "Influence of Succinic Acid on the Extracellular .alpha.-amylase Production by Chemostat-grown Bacillus Licheniformis", pp. 93-96, (1979).
Gandhi et al "Effect of Carbon Dioxide on the Formation of .alpha.-Amylase by Bacillus subtilis Growing in Cont. Batch Cultures", Biotechnol. and Bioeng. 1975, 17.
Fujio et al "Isoamylase Production by Aerobacter aerogenes" J. Ferment. Technol. vol. 50, No. 8, pp. 553, 1972.
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Chemical Abstracts, vol. 89, 1978 No. 193652h Wiersma et al.
Bacteriol. Rev. 41 (3): (1977) Priest "Extracellular Enzyme Synthesis in the Genus Bacillus".

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