Processes for making proteins having anticoagulant properties

Details Processes for making proteins having anticoagulant properties Processes for making proteins having anticoagulant properties

1993-04-28

1994-07-12

Hill, Jr., Robert J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

4352523, 435 691, 4353201, 530324, 530334, C12P 2106, C12N 122, C07H 1512

Patent

active

053289978

ABSTRACT:
Proteins which specifically inhibit coagulation Factor Xa. The inhibitors, which do not inhibit Factor VIIa, kallikrein, trypsin, chymotrypsin, thrombin, urokinase, tissue plasminogen activator, plasmin, elastase, Factor XIa or S. aureus V8 protease, are polypeptides of 60 amino acid residues. The inhibitors may be purified from Ornithodoros moubata extract, synthesized, or produced using a recombinant DNA yeast expression system.

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