Chemistry: molecular biology and microbiology – Differentiated tissue or organ other than blood – per se – or... – Including perfusion; composition therefor
Patent
1986-10-08
1989-08-29
Warden, Robert J.
Chemistry: molecular biology and microbiology
Differentiated tissue or organ other than blood, per se, or...
Including perfusion; composition therefor
435173, 128395, 604 49, A01N 102, C12N 1300
Patent
active
048617040
ABSTRACT:
A patient's acceptance of a transplanted organ or tissue from a donor may be enhanced by irradiating donor-specific blood with ultraviolet-B radiation at a dosage of less than 1000 J/M.sup.2 so as to render the blood capable of inducing donor-specific immunological unresponsiveness in the patient, transfusing the irradiated, donor-specific blood into the patient prior to transplanting the organ or tissue into the patient to enhance subsequent acceptance of the organ or tissue by the patient, and thereafter transplanting the organ or tissue into the subject.
A patient's acceptance of transplanted organs and tissues can also be enhanced by removing the organ or tissue from the donor and irradiating the organ or tissue to be transplanted with ultraviolet-B radiation at a dosage of less than 1000 J/m.sup.2 so as to enhance acceptance of the transplanted organ or tissue and then transplanting the irradiated organ or tissue into patient.
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Hardy Mark A.
Lau Henry T.
Reemtsma Keith
Deck Randall E.
The Trustees of Columbia University in the City of New York
Warden Robert J.
White John P.
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