Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4

Details Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4 Processes for (3S,4R)-3-[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4

1991-01-18

1991-12-24

Berch, Mark L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Unsubstituted hydrocarbyl chain between the ring and the -c-...

540357, C07D20509, C07D40912, C07B 3710, C07F 718

Patent

active

050754394

ABSTRACT:
Improved processes for preparation of racemic, cis- and optically active (3S,4R)-3[1(R)-t-butyl-dimethylsilyloxy)-ethyl]-4-[1-oxo-3-thiolanylthio(t hiocarbonyl)thio]azetidin-2-ones, process improvements for certain intermediates therefor and a novel intermediate for said racemic, cis- and trans-compounds, which compounds are useful as intermediates for antibacterial 5R,6S-6-[1(R)-hydroxyethyl]-2-(1-oxo-3-thiolanylthio)-2-penem-3-carboxylic acids and the pharmaceutically-acceptable salts and the pivaloyloxymethyl esters thereof.

REFERENCES:
patent: 4585767 (1986-04-01), Cooke et al.
patent: 4595539 (1986-06-01), Hamanaka
patent: 4614614 (1986-09-01), Ernest et al.
patent: 4619783 (1986-10-01), Hamanaka
patent: 4619924 (1986-10-01), Hamanaka
patent: 4739047 (1988-04-01), Volkmann et al.
patent: 4740595 (1988-04-01), Chackalamannil
patent: 4882429 (1989-11-01), McCombie
Endo, Can. J. Chem., 65, 2140 (1987).
Leanza et al., Tetrahedron, 39, 2505 (1983).
Yoshida et al., Chem. Pharm. Bull. 29, 2899 (1981).
Alpegiani et al., Tetrahedron Lett., 24, 1627 (1983).
Hirai et al., Tetrahedron Lett., 23, 4021, 4025 (1982).
Yanagisawa, Tet. Letters 24, 1037-40.
Shiozaki, Tet. Letters 22, 5205 (1981).
Maruyana, Tet. Letters 26, 4521 (1985).

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