Processes and intermediates useful to make antifolates

Details Processes and intermediates useful to make antifolates Processes and intermediates useful to make antifolates

1999-10-06

2000-07-18

Kight, John

Fuel and related compositions

Solid carbonaceous fuel dispersed in a liquid medium

560 53, 560 51, 560 8, 560103, 560 55, 560 64, C07D48704, C07C 6976

Patent

active

060901683

ABSTRACT:
The present application relates to a series of novel sulfonic acid metal cation salts of the formula ##STR1## which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula ##STR2## from the corresponding sulfonic acid metal cation salts.

REFERENCES:
patent: 4260771 (1981-04-01), Cragoe, Jr. et al.
Larock, R. C. et al. : Synthesis of aryl-substituted aldehydes and ketones via palladium-catalyzed coupling of aryl halides and non-allylic unsaturated alcohols. Tetrahed. Lett. vol. 30, pp. 6629-6632, 1989.

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