Processes and intermediates useful to make antifolates

Details Processes and intermediates useful to make antifolates Processes and intermediates useful to make antifolates

1998-09-24

2000-01-11

Rotman, Alan L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

560 8, 560 19, 560 38, C07C31500, C07C 6976

Patent

active

060138289

ABSTRACT:
The present application relates to a series of novel sulfonic acid metal cation salts of the formula ##STR1## which are useful intermediates to prepare antifolate 5-substituted pyrrolo[2,3-d]pyrimidines. The present invention also relates to a novel process for preparing the sulfonic acid metal cation salts and to a novel process for preparing aldehydes of the formula ##STR2## from the corresponding sulfonic acid metal cation salts.

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