Processes and intermediates for the preparation of 5-oxygenated

Details Processes and intermediates for the preparation of 5-oxygenated Processes and intermediates for the preparation of 5-oxygenated

1990-03-15

1991-10-22

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

549292, 544 69, 544149, 544584, 544226, 544374, 546 14, 546206, C07F 718, C07D30910

Patent

active

050596969

ABSTRACT:
This invention discloses novel intermediates and novel process for their preparation where said intermediates are useful for the preparation of 5-oxygenated derivatives (T) of lovastatin and analogs thereof at the 8-acyl side chain and 6-position of the polyhydronaphthyl ring. Said derivatives of lovastatin (T) and analogs thereof are useful in treating hypercholesterolemia and are disclosed in the U.S. Pat. No. 4,963,538. ##STR1##

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Kuo et al., J. Org. Chem., "Reductive Transformation of Cyclopropanation of Mevinolin (6.alpha.-Methylcompactin)", 48, 1991-1998 (1983).
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Evans et al, J. Org. Chem., 54, 2440 (1989).
Matteson et al, Tetrahedron Lett., 449 (1980).
M. Schroder, Chem. Rev., 80, 187 (1980).
Matteson et al, J. Org. Chem., 54, 2742 (1989).

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