Processes and intermediates for synthetic antibody derivatives

Details Processes and intermediates for synthetic antibody derivatives Processes and intermediates for synthetic antibody derivatives

1995-03-13

2000-10-24

Achutamurthy, Ponnathapura

Drug, bio-affecting and body treating compositions

Conjugate or complex of monoclonal or polyclonal antibody,...

4241341, 4241791, 424809, 5303871, 5303873, 5303911, 5303919, A61K 39395, C07K 1600, C07K 1700

Patent

active

061363138

ABSTRACT:
This invention is directed to intermediates for use in the preparation of chimeric antibodies and synthetic antibody derivatives. The intermediates are open- or closed-hinge Fc fragments that have at least one alkylated external sulphydryl group. The invention is also directed to processes for making such intermediates, chimeric antibodies or synthetic antibody derivatives produced from the intermediates, and to methods of treating B-cell Lymphoma by administering chimeric antibodies or synthetic antibody derivatives produced using the intermediates of the invention.

REFERENCES:
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Rudinger, J., Peptide Hormones, Parsons (edited), University Park Press, pp. 1-7 (1976).
Stevenson et al. (1985a) Cancer Surveys 4(1):213-244.
Watts et al., (1985) Mol. Immunol. 22(7):803-810.

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