Processes and intermediates for resolving piperidyl...

Details Processes and intermediates for resolving piperidyl... Processes and intermediates for resolving piperidyl...

2006-02-23

2008-12-02

Andres, Janet L. (Department: 1625)

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C546S190000

Reexamination Certificate

active

07459560

ABSTRACT:
Processes and intermediates for preparing 2-substituted piperidines such as 2-substituted d-threo piperidines are provided, including processes and intermediates for resolution of piperidyl acetamide stereoisomers.

REFERENCES:
patent: 2507631 (1950-05-01), Hartmann et al.
patent: 2838519 (1958-06-01), Rometsch et al.
patent: 2957880 (1960-10-01), Rometsch
patent: 4137300 (1979-01-01), Sheth et al.
patent: 4410700 (1983-10-01), Rice
patent: 4794001 (1988-12-01), Mehta et al.
patent: 4882166 (1989-11-01), Graham et al.
patent: 4904476 (1990-02-01), Mehta et al.
patent: 4968505 (1990-11-01), Okada et al.
patent: 4986987 (1991-01-01), Ayer et al.
patent: 4992445 (1991-02-01), Lawter et al.
patent: 5104899 (1992-04-01), Young et al.
patent: 5114946 (1992-05-01), Lawter et al.
patent: 5133974 (1992-07-01), Paradissis et al.
patent: 5137733 (1992-08-01), Noda et al.
patent: 5156850 (1992-10-01), Wong et al.
patent: 5158777 (1992-10-01), Abramowitz et al.
patent: 5160744 (1992-11-01), Jao et al.
patent: 5202128 (1993-04-01), Morella et al.
patent: 5217718 (1993-06-01), Colley et al.
patent: 5223265 (1993-06-01), Wong
patent: 5229131 (1993-07-01), Amidon et al.
patent: 5232705 (1993-08-01), Wong et al.
patent: 5236689 (1993-08-01), Wong et al.
patent: 5283193 (1994-02-01), Yamamoto et al.
patent: 5284769 (1994-02-01), Evans et al.
patent: 5299121 (1994-03-01), Brill et al.
patent: 5308348 (1994-05-01), Balaban et al.
patent: 5326570 (1994-07-01), Rudnic et al.
patent: 5331000 (1994-07-01), Young et al.
patent: 5362755 (1994-11-01), Barberich et al.
patent: 5375693 (1994-12-01), Woosley et al.
patent: 5391381 (1995-02-01), Wong et al.
patent: 5425950 (1995-06-01), Dandiker et al.
patent: 5449743 (1995-09-01), Kobayashi et al.
patent: 5478573 (1995-12-01), Eichel et al.
patent: 5496561 (1996-03-01), Okada et al.
patent: 5500227 (1996-03-01), Oshlack et al.
patent: 5512293 (1996-04-01), Landrau et al.
patent: 5567441 (1996-10-01), Chen
patent: 5580578 (1996-12-01), Oshlack et al.
patent: 5593694 (1997-01-01), Hayashida et al.
patent: 5639476 (1997-06-01), Oshlack et al.
patent: 5672360 (1997-09-01), Sackler et al.
patent: 5733478 (1998-03-01), Creech et al.
patent: 5733756 (1998-03-01), Zeitlin et al.
patent: 5837284 (1998-11-01), Mehta et al.
patent: 5874090 (1999-02-01), Baker et al.
patent: 5908850 (1999-06-01), Zeitlin et al.
patent: 5922736 (1999-07-01), Dariani et al.
patent: 5936091 (1999-08-01), Khetani et al.
patent: 5965734 (1999-10-01), Ramaswamy et al.
patent: 6031124 (2000-02-01), Fox et al.
patent: 6062997 (2000-05-01), Seymour
patent: 6113879 (2000-09-01), Richards et al.
patent: 6121453 (2000-09-01), Zavareh
patent: 6127385 (2000-10-01), Midha et al.
patent: 6217904 (2001-04-01), Midha et al.
patent: 6221883 (2001-04-01), Baldessarini
patent: 6228398 (2001-05-01), Devane et al.
patent: 6242464 (2001-06-01), Harris et al.
patent: 6255325 (2001-07-01), Dariani et al.
patent: 6344215 (2002-02-01), Bettman et al.
patent: 6355656 (2002-03-01), Zeitlin et al.
patent: 6359139 (2002-03-01), Khetani et al.
patent: 6395752 (2002-05-01), Midha et al.
patent: 6441178 (2002-08-01), Zavareh et al.
patent: 6468504 (2002-10-01), Richards et al.
patent: 6486177 (2002-11-01), Zeldis et al.
patent: 6528530 (2003-03-01), Zeitlin et al.
patent: 6531489 (2003-03-01), Harris et al.
patent: 6602887 (2003-08-01), Dariani et al.
patent: 6635284 (2003-10-01), Mehta et al.
patent: 6730325 (2004-05-01), Devane et al.
patent: 7115631 (2006-10-01), Zeldis et al.
patent: 2002/0019535 (2002-02-01), Zavareh et al.
patent: 2002/0032335 (2002-03-01), Langston et al.
patent: 2002/0103162 (2002-08-01), Epstein et al.
patent: 2002/0132793 (2002-09-01), Epstein et al.
patent: 2003/0049205 (2003-03-01), Richards et al.
patent: 2003/0105134 (2003-06-01), Harris et al.
patent: 2003/0170181 (2003-09-01), Midha
patent: 1 297 368 (1992-03-01), None
patent: 2 368 367 (2000-10-01), None
patent: 2 376 215 (2001-12-01), None
patent: 2 223 643 (2003-12-01), None
patent: 0 636 366 (1995-02-01), None
patent: 0 885 191 (2002-01-01), None
patent: 0 889 874 (2002-01-01), None
patent: 0 841 928 (2002-09-01), None
patent: 0 879 228 (2002-10-01), None
patent: 0 958 281 (2004-03-01), None
patent: 2 635 460 (1994-09-01), None
patent: 589625 (1945-01-01), None
patent: 788226 (1957-12-01), None
patent: 878167 (1961-09-01), None
patent: 466229 (1975-04-01), None
patent: 93/05769 (1993-01-01), None
patent: 97/03671 (1997-02-01), None
patent: 97/03672 (1997-02-01), None
patent: 97/03673 (1997-02-01), None
patent: 97/27176 (1997-07-01), None
patent: 97/28124 (1997-08-01), None
patent: 97/32851 (1997-09-01), None
patent: 97/35836 (1997-10-01), None
patent: 98/06380 (1998-02-01), None
patent: 98/23263 (1998-06-01), None
patent: 98/25902 (1998-06-01), None
patent: 98/31668 (1998-07-01), None
patent: 98/14168 (1998-09-01), None
patent: 99/62496 (1999-12-01), None
patent: 00/74680 (2000-12-01), None
patent: 01/43730 (2001-06-01), None
patent: 2004/026258 (2004-04-01), None
Berrang, et al., “Enantiomeric aminopropiophenones,” CA 97:38738, 1982.
Branko, et al., “Determination of enantiomeric composition of 1-phenyl-2(2-piperidyl) acetamide,” Tetrahedron: Asymmetry, 1994, 5, 1711-1716.
Brown, G., “The use of methylphenidate for cognitive decline associated with HIV disease,” Int'l J. Psychiatry Med., 1995, 25(1), 21-37.
Dobashi, et al., “Enantioselectivity of hydrogen-bond,” CA 106:66522, 1986.
Greenhill, “Attention Deficit Hyperactivity Disorder”, Pediatric Psychopharmacology, 1995, 4(1), 123-168.
Japan Chem. Soc., “Organic reaction,” 1958, 1(18), 504-505 (translation attached).
Patrick, et al., “Synthesis of deuterium labeled methylphenidate,” J. Label. Pharm., 1982, 9, 484-490.
Vanderplas, B. et al., “A convenient synthesis of cis-1R-N-benzyl-2S-hydroxymethyl cyclohexylamine,” CA 118:101538, 1992.
Aoyama, T., et al., “Nonlinear kinetics of threo-methylphenidate enantiomers in a patient with narcolepsy and in healthy volunteers,” Eur. J. of Clinical Pharmacology, 1993, 44(1), 79-84.
Barkley, R. A., et al., “The adolescent outcome of hyperactive children diagnosed by research criteria: I. An 8-year prospective follow-up study,” J. Am. Acad. Adolesc. Psychiatry., 1990, 29(4), 546-557.
Bruera, E., et al., “The uses of psychotropics in symptom management in advanced cancer,” Psycho-Oncology., 1998, 7, 346-358.
CAS RN6051-31-6 or RN 3019-58-7.
Feng, et al., “Molecular determinants of the platelet,” CA 117:111440, 1992.
Garland, E. J., “Pharmacotherapy of adolescent attention deficit hyperactivity disorder: challenges, choices and caveats,” J. Psychopharmacology., 1998, 12(4), 385-395.
Golden, G. S., “Role of attention deficit hyperactivity disorder in learning disabilities,” Seminars in Neurology., 1991, 11(1), 35-41.
Goldman, L. S., et al., “Diagnosis and treatment of attention-deficit/hyperactivity disorder in children and adolescents,” J. Am. Med. Assn., 1998, 279(14), 1100-1107.
Jursic, et al., “Determination of enantiomeric composition of 1-phenyl-2(2-piperidinyl-acetamide),” Tetrahedron: asymmetry, 1994, 5, 1711-1716.
Morrison, et al., “Organic Chemistry,” Allyn & Bacon, 1973, 32-34.
No author, “Methylphenidate hydrochloride,” Environmental Health Perspectives, 1997, 105 (supp 1), 319.
Ohashi, N. et al., “Acyl(amino)naphthalene derivatives,” CA 104:186157, 1985.
Spencer, T., et al., “Pharmacotherapy of attention-deficit hyperactivity disorder across the life cycle,” J. Am. Acad. Adolesc. Psychiatry., 1996, 35(4), 409-432.
Srinivas et al., “Enantioselective pharmacokinetics and pharmacodynamics of racemic threo-methylphenidate in children with attention deficit hyperactivity disorder,” Clin. Pharmacol. Ther., 1995, 52(2), 561-568.
Stein, M. A., et al., “Methylphenidate dosing: Twice daily versus three times daily,” Pediatrics, 1996, 98(

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