Processes and intermediates for preparing 2-fluorothiophene deri

Details Processes and intermediates for preparing 2-fluorothiophene deri Processes and intermediates for preparing 2-fluorothiophene deri

1999-11-30

2000-08-01

Lambkin, Deborah C.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

C07D33338

Patent

active

060969016

ABSTRACT:
A process for the preparation of the compound of the formula: ##STR1## wherein R.sup.1 is OH, which comprises the steps of a) treating the compound of the formula: ##STR2## with an inorganic fluoride, of the formula M.sup.2 F wherein M.sup.2 is an alkali metal cation, at an elevated temperature in the presence of a compound of the formula R.sup.4 P.sup.+ Z.sup.- and a compound of the formula R.sup.5 vic (COW).sub.2 wherein R.sup.4 and R.sup.5 are each selected from optionally substituted (C.sub.6 -C.sub.10) aryl and optionally substituted (C.sub.1 -C.sub.6) alkyl, and W is halo; to form the compound of the formula: ##STR3## and b) I) treating the compound of the formula IV with an aqueous solution of a base, of the formula MOH, wherein M is an alkali metal cation, and

REFERENCES:
patent: 5290802 (1994-03-01), Ehrgott et al.
patent: 5648502 (1997-07-01), Burgess et al.
patent: 5688969 (1997-11-01), Orban
patent: 5789437 (1998-08-01), Elbe et al.
patent: 6043379 (2000-03-01), Marfat et al.
Gronowitz, S.--Chem. Abst.--vol. 75, No. 3, Jul. 19, 1971, Abst No. 20080c, Nuclear Magnetic Resonance of aromatic heterocyclics. III On the synthesis of substituted fluorothiophenes.
Gronowitz, S.--Chem.Scripta, vol. 1., pp. 33-43, 1971, Nuclear Magnetic Resonance of aromatic heterocyclics. III On the synthesis of substituted fluorothiophenes.
Suzuki, H.--Chem. Soc. Japan, Bull Chem Soc. Jpn, vol 63.,No. 7, pp. 2010-2017, (1990) General & Highly Eff. Syntheses of m-Fluoro Arenes Using Potassium Fluoride-Exchange Method.
Yazawa, N.--Chem. Letters. (1989)--pp. 2213-2216, Chem Soc. Of Japan--Tetraphenyphosphonium Bromide catalyzed . . . .
Heinz, P.--Chem. abst., vol. 89, p. 553--Abst. No. 163322h--Nov. 6, 1978--Some thienyl analogs of amidnomycin.
Dann, O.--Chem. Abst. vol. 37, No. 21--Col. 6260, Nov. 10, 1943--Amiocarbixylic ester of furan, thiophene & thiazole.

Affiliated with

Also associated with

Rating

Processes and intermediates for preparing 2-fluorothiophene deri does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Processes and intermediates for preparing 2-fluorothiophene deri, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Processes and intermediates for preparing 2-fluorothiophene deri will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-665392