Processes and devices for continuously monitoring levels of anal

Details Processes and devices for continuously monitoring levels of anal Processes and devices for continuously monitoring levels of anal

1996-07-11

1997-04-01

Sykes, Angela D.

Surgery

Truss

Pad

128630, 128637, G01N 27404

Patent

active

056156715

ABSTRACT:
In a process and devices or continuously measuring the concentration of an analyte in tissue. The tissue is provided with a hollow fiber having a pore size between the size of the analyte and the size of macromolecules, hollow fiber is perfused with a solution compatible with the tissue, and that solution is supplied from the hollow fiber through a reactor for the analyte. The reactor has a second hollow fiber having a pore size between the size of the analyte and the size of macromolecules, and the second hollow fiber is located in a container which contains macromolecular reactants for detecting the analyte and a signal producing system coupled therewith. The perfusion fluid is fed from the reactor to an eliminator for the analyte, whereby at least 95% of the remaining analyte is removed from the perfusion fluid and the perfusion fluid is reintroduced into said first hollow fiber.
The process and devices operate as a closed circuit and therefore this method can be continued over a longer period of time than known methods, without the need to replace reservoirs.

REFERENCES:
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patent: 4192748 (1980-03-01), Hyden
patent: 4247647 (1981-01-01), Barabino et al.
patent: 4832034 (1989-05-01), Pizziconi
patent: 5001054 (1991-03-01), Wagner
patent: 5399256 (1995-03-01), Bohs et al.
patent: 5425868 (1995-06-01), Pedersen

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