Processed starch, process for preparing same and use of same in

Details Processed starch, process for preparing same and use of same in Processed starch, process for preparing same and use of same in

1981-06-10

1983-05-10

Griffin, Ronald W.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

106210, 106213, C08B 3100

Patent

active

043831117

ABSTRACT:
A processed starch useful as a disintegrant to be incorporated into medicines is provided. The processed starch consists essentially of substantially non-birefringent starch powder which substantially retains the shell film structure of green starch granules. The starch powder has a particle size distribution substantially free of a fraction having a size of 48 Tyler standard sieve mesh or having a larger size, and has a bulk density of at least about 0.25 g/cc, a cold water-soluble component content of less than 10% by weight, a swelling volume of about 3 to about 15 ml/g and a water retention of at least about 2. The processed starch is prepared by a process wherein water and, if necessary, an organic solvent is added to green starch to form a dispersion having a solid a component concentration of not more than 60%; the dispersion is heated to render the green starch granule non-birefringent by swelling the green starch granule without destruction of the shell film structure thereof; and then, the dispersion is dried without destruction of the shell film structure.

REFERENCES:
patent: 2614945 (1952-10-01), Krisan
patent: 3071492 (1963-01-01), Satterly
patent: 3622677 (1971-11-01), Short et al.
patent: 4072535 (1978-02-01), Short et al.
patent: 4104212 (1978-08-01), Bruner
patent: 4104213 (1978-08-01), Chiang et al.

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