Process using achiral co-catalyst promoter for chiral phase tran

Details Process using achiral co-catalyst promoter for chiral phase tran Process using achiral co-catalyst promoter for chiral phase tran

1985-12-06

1986-08-12

Killos, Paul J.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

560 53, 568326, 568327, C07C 6994

Patent

active

046057617

ABSTRACT:
An improved method for the direct preparation of an enantiomer of a substituted fluorenyloxyacetic acid including the enhancement of a chiral phase transfer alkylation step in the synthesis using a non-ionic surfactant as co-catalyst. The substituted fluorenyloxyacetic acid is useful in the treatment of brain edema.

REFERENCES:
patent: 3704314 (1972-11-01), Cragoe, Jr. et al.
patent: 3903145 (1975-09-01), Levine et al.
patent: 4070539 (1978-01-01), Cragoe, Jr. et al.
patent: 4316043 (1982-02-01), Cragoe, Jr. et al.
patent: 4317922 (1982-03-01), Cragoe, Jr. et al.

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