Process to simvastatin ester

Details Process to simvastatin ester Process to simvastatin ester

1991-05-01

1992-10-27

Ivy, C. Warren

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acid esters

549292, C07C 6974, C07D30930

Patent

active

051591049

ABSTRACT:
A process is disclosed, for the formation of simvastatin, which comprises the sequential acylation of a diol lactone to form a bis acylated intermediate followed by selective deacylation and lactone ring closure to form simvastatin.

REFERENCES:
patent: 4293496 (1981-10-01), Willard
patent: 4444784 (1984-04-01), Hoffman et al.
patent: 4582915 (1986-04-01), Sleteinger et al.
patent: 4584389 (1986-04-01), Sletzinger et al.
patent: 4820850 (1989-04-01), Verhoeven et al.
patent: 4866090 (1989-09-01), Hoffman et al.
W. F. Hoffman et al., II. 3-Hydroxy-3-Methylglutaryl-Coenzyme A Reductase Inhibitors, J. Med. Chem., 29, 849 (1986).

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