Process to separate mixtures of enantiomeric arylpropionic acids

Details Process to separate mixtures of enantiomeric arylpropionic acids Process to separate mixtures of enantiomeric arylpropionic acids

1989-06-27

1991-01-08

Lone, Werren B.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562402, 562460, 562492, 562496, C07B 5700

Patent

active

049837656

ABSTRACT:
A process is described in which a mixture of enantiomeric arylpropionic acid is split and one of enantiomeric forms of the acid is recovered. The mixture is transformed into a diastereoisomeric salt by a reaction with a chiralic base and an inert solvent, and the desired acid enantiomer is removed from the reaction product. The transformation to a diastereoisomeric salt takes place in a polar solvent. The salt produced is recrystallized several times and the thus purified salt is split in a dilute mineral acid.

REFERENCES:
patent: 4515811 (1985-05-01), Holton
patent: 4752417 (1988-06-01), Inoue et al.

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