Process to produce midazolam

Details Process to produce midazolam Process to produce midazolam

1998-04-20

1999-07-13

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heavy metal containing

540562, C07D21114, C07D20706

Patent

active

059228920

ABSTRACT:
The present invention discloses new processes in the preparation of midazolam (VII), ##STR1## a commercially important pharmaceutical, as well a new intermediates in those processes from a known benzophenone (I) starting material.

REFERENCES:
patent: 3932325 (1976-01-01), Nakanishi et al.
patent: 4280957 (1981-07-01), Walser et al.
patent: 4377523 (1983-03-01), Walser et al.
J. Heterocyclic Chem., 13, pp. 433-437 (1976).
J. Org. Chem., 43, pp. 936-944 (1978).
Aldrichimica Acta, 23(1), pp. 13-19 (1990).
Tetrahedron Letters, 35(35), pp. 6567-6570 (1994).
J. Org. Chem., 40(2), 153 (1975).

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