Process to prepare pyrimidine nucleosides

Details Process to prepare pyrimidine nucleosides Process to prepare pyrimidine nucleosides

1997-10-23

1999-08-03

Kunz, Gary L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carbohydrates or derivatives

536 553, C07H 100, C07H 19073

Patent

active

059327197

ABSTRACT:
A process for the production of a compound of the formula: ##STR1## wherein R.sub.1 is hydrogen, alkyl C.sub.1 -C.sub.16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl, cyano, carboxy, carboxy esters, carboxamido, N-mono substituted and N,N-disubstituted carboxamido with alkyl, aralkyl and aryl groups; R.sub.2 is hydrogen, alkyl C.sub.1 -C.sub.16 substituted alkyl, aryl, substituted aryl, aralkyl, substituted aralkyls, alkenyl, substituted alkenyl, alkynyl, substituted alkynyl; R.sub.3 is alkyl C.sub.2 -C.sub.6, branched alkyl, aryl C.sub.2 -C.sub.6, substituted aryl and R.sub.4 is halogen or H.
A condensation reaction is effected between compounds of the formulae: ##STR2## to form a novel compound of the formula: ##STR3## Compound (2) is acylated with a compound of the formula:

REFERENCES:
patent: 5760208 (1998-06-01), Abushanab et al.
Pragnacharulu et al. J. Org. Chem. 60: 3096-3099, 1995.
Barvian et al. J. Org. Chem. 58: 6151-6154, 1993.
Rao et al. J. Chem. Soc. Commun. 1255-1256, 1994.
Sawai et al. Chem. Lett. 605-606, 1994.
Sawai et al. J. Chem. Soc. Chem. Commun. 1997-1998, 1994.

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