Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2011-03-15
2011-03-15
Saeed, Kamal A (Department: 1626)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C548S306400
Reexamination Certificate
active
07906541
ABSTRACT:
The invention relates to a new process leading to new substituted 1H-benzo[d]imidazol-2(3H)-ones of formula III and III′, to pharmaceutical compositions comprising them and to their use as therapeutic agents, particularly as BACE 1 inhibitors in the treatment of Alzheimer disease.
REFERENCES:
patent: 2006/0183790 (2006-08-01), Cole et al.
patent: 2008013925 (2008-01-01), None
patent: 2008032164 (2008-03-01), None
patent: 2008051533 (2008-05-01), None
patent: 2008061968 (2008-05-01), None
patent: 2008065508 (2008-06-01), None
patent: 2008070150 (2008-06-01), None
patent: 2008070264 (2008-06-01), None
patent: 2008070268 (2008-06-01), None
patent: 2008115552 (2008-09-01), None
Duarte, CD et al. Privileged Structures: A Useful Concept for the Rational Design of New Lead Drug Candidates. Mini-Reviews in Medicinal Chemistry. 2007. Benthan Science Publishers. vol. 7. pp. 1108-1119.
Kubinyi, Hugo. Privileged Structures and Analogue-Based Drug Discovery. In Analogue-Based Drug Discovery. 2006. pp. 53-68.
Zou, B et al. Cascade Coupling/Cyclization Process to N-Substituted 1,3-Dihydrobenzimidazol-2-ones. Organic Letters. 2007. American Chemical Society. vol. 9. No. 21. pp. 4291-4294.
Xu, X et al. Microwave-assisted traceless synthesis of benzimidazolones. Tetrahedron Letters 48 (2007). 2006. Elsevier. pp. 129-132.
McLaughlin, M et al. Efficient Access to Cyclic Ureas via Pd-Catalyzed Cyclization. Organic Letters. 2006. American Chemical Society. vol. 8. No. 15. pp. 3311-3314.
Kuethe, JT et al. Rearrangement of spiro-benzimidazolines: preparation of N-alkenyl- and N-alkyl-benzinnidazol-2-ones. Tetrahedron 63 (2007). 2007. Elsevier. pp. 11489-11502.
Roussel, C et al. New Route to 3-Alkylthiazolo[3,2-a]benzimidazole Derivatives. Molecules. 2005. MDPI. vol. 10. pp. 327-333.
Edwards, PD et al. Application of Fragment-Based Lead Generation to the Discovery of Novel, Cyclic Amidine β-Secretase Inhibitors with Nanomolar Potency, Cellular Activity, and High Ligand Efficiency. J. Med. Chem. 2007. American Chemical Society. vol. 50. pp. 5912-5925.
European Search Report, EP 08 29 1046 dated Mar. 24, 2009.
Andreoli Frederico
Roussel Christian
Vanthuyne Nicolas Daniel Pierre
Bianchi Kristin
Craig Lesley S.
Saeed Kamal A
Universite Paul Cezanne-Aix Marseille III
LandOfFree
Process to prepare new substituted 1 H -benzo[ d... does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Process to prepare new substituted 1 H -benzo[ d..., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process to prepare new substituted 1 H -benzo[ d... will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-2765057