Organic compounds -- part of the class 532-570 series – Organic compounds – Heavy metal containing
Patent
1990-12-11
1992-04-21
Prescott, Arthur C.
Organic compounds -- part of the class 532-570 series
Organic compounds
Heavy metal containing
556110, 546 88, C07F 108
Patent
active
051070057
ABSTRACT:
This invention refers to a process to obtain new mixed copper aminoacidates complexes from phenanthrolines of an aromatic type to be used as anticancerigenic agents preferably with a therapeutic use for the treatment of liquid and solid cancerigenic tumors such as leukemia. The complexes obtained are of the [Cu (N-N) (N-O)].+-. NO.sub.3 type in which the N-N ligand corresponds to 4, 7 - diphenyl-1, 10 phenanthroline and the N-O ligand preferably corresponds to one of the aminoacidates such as glycinate, alaninate, isoleucinate, leucinate, serinate and valinate. The process is characterized because it includes the following steps: making an aqueous solution based on an aliphatic alcohol and 4, 7 - diphenyl - 1, 10 phenanthroline react with a copper complex preferably Cu NO.sub.3 5H.sub.2 O at room temperature, and immediately after making the obtained product react in an aqueous aminoacidate solution adjusting a slightly alkaline pH.
REFERENCES:
patent: 4965384 (1990-10-01), Cliffton et al.
patent: 5041573 (1991-08-01), Hasegana et al.
Prescott Arthur C.
Universidad Nacional Autonoma de Mexico (UNAM)
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