Process to obtain dibenzylbutyrolactonic lignans, process to...

Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...

Reexamination Certificate

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C549S435000

Reexamination Certificate

active

10508875

ABSTRACT:
The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves ofZanthoxylum naranjilloorPiper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6′-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.

REFERENCES:
Badheka et al Phytochemistry, 25, 487-489, 1986.
Silva et al. Phytotherapy Research, 2007, 21(5), pp. 420-422.

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