Organic compounds -- part of the class 532-570 series – Organic compounds – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2008-01-08
2008-01-08
Seaman, D. Margaret (Department: 1625)
Organic compounds -- part of the class 532-570 series
Organic compounds
Heterocyclic carbon compounds containing a hetero ring...
C549S435000
Reexamination Certificate
active
07317114
ABSTRACT:
The invention refers to a process to obtain lignans, especially to obtain cubebin and methylpluviatolide from leaves ofZanthoxylum naranjilloorPiper cubeba. It also refers to a process to obtain semi-synthetic derivatives of cubebin, especially dibenzylbutirloactonic lignans, such as: hinokinin, o-acetyl cubebin, o-methyl cubebin, 6,6′-dinitrohinokinine and o-dimethylethylamine cubebin and other derivatives which may be obtained, as well as to obtain methylpluviatolide derivatives, which are used to manufacture drugs to provide activity at least five times higher than observed for gentian violet and other compounds used heretofore for blood treatment and Chagas' disease prophylaxis.
REFERENCES:
Badheka et al Phytochemistry, 25, 487-489, 1986.
Silva et al. Phytotherapy Research, 2007, 21(5), pp. 420-422.
Albuquerque Sérgio
Bastos Jairo Kenupp
Silva Márcio Luis Andrade
Silva Rosângela
Souza Gustavo Henrique Bianco
Chandrakumar Nizal S.
Fundacao de Amparo a Pesquisa do Estado de Sao Paulo
Seaman D. Margaret
Volpe & Koenig PC
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