Process to manufacture micronized nifedipine granules for sustai

Details Process to manufacture micronized nifedipine granules for sustai Process to manufacture micronized nifedipine granules for sustai

1994-09-29

1996-08-06

Dawson, Robert A.

Plastic and nonmetallic article shaping or treating: processes

Forming articles by uniting randomly associated particles

With liberating or forming of particles

264117, 264122, 424470, B29B 916

Patent

active

055430996

ABSTRACT:
The subject invention is a process to manufacture a sustained release pharmaceutical tablet. The process includes granulation of inactive ingredients, such as hydroxypropyl cellulose, with active ingredients, such as nifedipine; followed by micronization of the granules. Additional granulation of further active or inactive ingredients is done with or without the micronized granules formed in the first step. All of the granules are then dried if necessary, lubricated, and compressed into tablets which slowly release the active ingredient over a controlled length of time.

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