Process to make chiral compounds

Organic compounds -- part of the class 532-570 series – Organic compounds – Amino nitrogen containing

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564285, 564287, 564363, C07G20988

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active

06008412&

ABSTRACT:
The present invention relates to processes for resolving N-methyl-3(R,S)-hydroxy-3-phenylpropylamine and N,N-dimethyl-3 (R,S) -hydroxy-3-phenylpropylamine with the isomers of mandelic acid and the resulting salts.

REFERENCES:
patent: 4765826 (1988-08-01), Van Heertum et al.
patent: 5527821 (1996-06-01), Willman et al.
Robertson, D. W., et al., Absolute Configurations and Pharmaceutical Activities of the Optical Isomers of Fluoxetine, A Selective Serotonin-Uptake Inhibitor Journal of Medicinal Chemistry, vol. 31, No. 7, Jul. 1, 1988, pp. 1412-1417.

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