Process to inhibit binding of the integrin .alpha..sub.4 .beta..

Details Process to inhibit binding of the integrin .alpha..sub.4 .beta.. Process to inhibit binding of the integrin .alpha..sub.4 .beta..

1998-04-13

2000-07-11

MacMillan, Keith D.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 9, 530317, 530329, A61K 3812, C07K 764

Patent

active

060873302

ABSTRACT:
The present invention is directed to an isolated and purified cyclic peptide of from 5 to about 13 residues modeled after a portion of the CS1 peptide. A peptide of this invention preferably has the amino acid residue sequence of SEQ ID NO:2-14 or 16-42. The present invention is further directed to a process of selectively inhibiting the binding of .alpha..sub.4 .beta..sub.1 integrin to a protein such as VCAM-1, fibronectin or invasin. In accordance with that process, a cell that expresses .alpha..sub.4 .beta..sub.1 integrin is exposed to that protein in the presence of an effective inhibiting amount of such a peptide. The present invention is still further directed to a pharmaceutical composition containing a physiologically acceptable carrier and a cyclic peptide of the invention.

REFERENCES:
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patent: 5849693 (1998-12-01), Wells et al.
Pierschbacher et al., PNAS, vol. 81, pp. 5985-5988, (Oct. 1984).
Yamada, The Journal of Biological Chemistry, vol. 266(20), pp. 12809-12812 (Jul. 15, 1991).
Davies et al, Biochemical Society Transactions, vol. 18, pp. 1326-1328 (1990).
Ali et al, Peptides, Proceedings of the 11.sup.th Am. Pept. Symp., pp. 94-96, (Jul. 9-14, 1989).
Aumailley et al, FEBS, vol. 291(1), pp. 50-54, 1991.

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