Process to inhibit binding of the integrin .alpha..sub.4 62 .sub

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Peptide containing doai

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514 15, 514 16, 514 17, 514 18, 530327, 530328, 530329, 530330, 530345, A61K 3800, C07K 100

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active

055103324

ABSTRACT:
The present invention is directed to an isolated and purified peptide comprising the LDV domain of the CSI peptide sequence or single amino acid substitutent analog thereof. A preferred peptide has the amino acid residue sequences shown in SEQ ID NOs:8-14, 17-23, 25, 28, and 51. The present invention is further directed to a process of inhibiting the binding of .alpha..sub.4 .beta..sub.1 integrin to a protein such as VCAM-1 or fibronectin comprising exposing a cell that expresses .alpha..sub.4 .beta..sub.1 integrin to the protein in the presence of an effective inhibiting amount of such a peptide. The present invention is still further directed to a pharmaceutical composition comprising a peptide of SEQ ID NO:8-102.

REFERENCES:
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