Process to extract quassinoids

Details Process to extract quassinoids Process to extract quassinoids

2006-06-12

2008-07-29

Tate, Christopher R. (Department: 1655)

Drug, bio-affecting and body treating compositions

Plant material or plant extract of undetermined constitution...

Reexamination Certificate

active

07404972

ABSTRACT:
A means for the extraction and crystallization of quassinoids such as quassin and neoquassin from natural sources containing these compounds, using compounds that are Generally Recognized As Safe by the U.S. Food and Drug Administration is provided. In particular, a means for extraction that does not require use of lead acetate, chloroform, methanol, or diethyl ether is provided. The process includes a means of removing non-polar and very polar substances from an extracted residue to enhance crystallization of quassinoids from the residue.

REFERENCES:
patent: WO 2005/092329 (2005-10-01), None
Guo Z, Vangapandu S, Sindelar RW, Walker LA, Sindelar RD, “Biologically active quassinoids and their chemistry: potential leads for drug design,” Current Medicinal Chemistry, Jan. 2005;vol. 12(2):173-190.
Clark, “Quassin. I. The Preparation and Purification of Quassin and Neoquassin, with Information Concerning their Molecular Formulas,” Journal of The American Chemical Society, vol. 59, May 1937, p. 927-931.
Adams et al., “The Amaroids of Quassia. I. Quassin, Isoquassin and Neoquassin,” Journal of The American Chemical Society, vol. 72, Jan. 1950, p. 375-379.
Clark, “Quassin. IV. A Minor Constituent of Jamaica Quassia Wood,” Journal of the American Chemical Society, vol. 64, Dec. 1942, p. 2883-2884.
Polonsky, “Chemistry and Biological Acitvity of the Quassinoids,” Chemistry and Chemical Taxonomy of the Rutales, 1983, p. 247-266.
Okano et al., “Biologically Active Compounds from Simaroubaceous Plants,” Studies in Natural Products Chemistry, vol. 7, 1990, p. 369-404, Elsevier Science Publishing Company Inc., New York, New York.

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