Process to destroy biological activity in protein-containing fee

Chemistry: molecular biology and microbiology – Virus or bacteriophage – except for viral vector or... – Inactivation or attenuation; producing viral subunits

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426231, 426573, 426601, 426635, 426 98, 426 2, 530350, 424451, C12N 706

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active

057802882

ABSTRACT:
A product and process for animal feed ingredients free of biologically active proteins as well as bacteria and viruses. The process comprises the steps of: treating a proteinaceous mixture with alkali to cause the pH of the mixture to be raised to where proteins in the proteinaceous mixture will be solubilized to form a gel; maintaining the proteinaceous mixture at a temperature in a range between about 50.degree. to 55.degree. C.; adding if needed, sufficient lipid material, to the alkali-treated proteinaceous mixture to provide a dispersion with a ratio of lipid to proteinaceous mixture in a range from about 5 to 80, respectively; determining an optimum pH of solubilization expressed as an alkali hydrogen ion difference on a hydrogen ion difference curve, measuring rate of change of hydrogen ion difference per unit of acid equivalent, ceasing addition of alkali when the slope of the titration curve is essentially zero, adding an acid to the lipid material/proteinaceous mixture dispersion to cause the pH of the dispersion to be lowered to an acidic endpoint where the proteins encapsulate the lipid material; the acidic endpoint being defined by: i) determining a pH of encapsulation by titration, expressed as an acidic hydrogen ion difference on a hydrogen ion difference curve, ii) measuring rate of change of hydrogen ion difference per unit of acid equivalent, iii) ceasing addition of acid when the slope of the titration curve is essentially zero.

REFERENCES:
patent: 5514388 (1996-05-01), Rohwer
Prusiner, PNAs, vol. 90(1), pp. 1-5, 1993.

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