Process to create biomolecule and/or cellular arrays on metal su

Chemistry: molecular biology and microbiology – Measuring or testing process involving enzymes or... – Involving nucleic acid

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

430 5, C12Q 168, G03F 900

Patent

active

061271292

ABSTRACT:
Disclosed is a process to construct multi-component biomolecule or cellular arrays suitable for use in SPR imaging studies of large molecule, cellular/molecular, and cell/cell interactions. The success of the procedure hinges on the use of a reversible protecting group to modify reversibly .omega.-functionalized alkanethiols self-assembled on metal substrates.

REFERENCES:
patent: 5242828 (1993-09-01), Bergstrom et al.
patent: 5347395 (1994-09-01), Lautenschlager et al.
patent: 5359681 (1994-10-01), Jorgenson et al.
patent: 5374563 (1994-12-01), Maule
patent: 5418136 (1995-05-01), Miller et al.
patent: 5436161 (1995-07-01), Bergstrom et al.
patent: 5468606 (1995-11-01), Bogart et al.
patent: 5482830 (1996-01-01), Bogart et al.
patent: 5492840 (1996-02-01), Malmqvist et al.
patent: 5494829 (1996-02-01), Sandstrom et al.
patent: 5514501 (1996-05-01), Tarlov
patent: 5541057 (1996-07-01), Bogart et al.
patent: 5550063 (1996-08-01), Bogart
patent: 5552272 (1996-09-01), Bogart
patent: 5554541 (1996-09-01), Malmqvist et al.
patent: 5583643 (1996-12-01), Gass et al.
patent: 5629213 (1997-05-01), Kornguth et al.
patent: 5629214 (1997-05-01), Crosby
patent: 5631171 (1997-05-01), Sandstrom et al.
patent: 5639671 (1997-06-01), Bogart et al.
patent: 5647030 (1997-07-01), Jorsenson et al.
patent: 5688642 (1997-11-01), Chrisey et al.
patent: 5815278 (1998-09-01), Johnston et al.
patent: 5822073 (1998-10-01), Yee et al.
patent: 5835645 (1998-11-01), Jorgenson et al.
patent: 5858799 (1999-01-01), Yee et al.
patent: 5869272 (1999-02-01), Bogart et al.
Pale-Grosdemage et al., "Formation of Self-Assembled Monolayers by Chemisorption of Derivatives of Oligo(ethylene glycol) of Structure HS(CH2)11(oCH2CH2)mOH on Gold" J. Am. Chem. Soc. 113, pp. 12-20, 1991.
Brockman et al., "A Multistep Chemical Modification Procedure to Create DNA Arrays on Gold Surfaces for the Study of Protein-DNA Interactions with Surface Plasmon Resonance Imaging" J. Am. Chem. Soc. 121, pp. 8044-8051, 1999.
Frutos, A. G. et al, "Demonstration of a Word Design Strategy for DNA Computing on Surfaces," Nucleic Acids Research 25:4748-4757 (1997).
Frutos, A. G. et al, "Enzymatic Ligation Reactions of DNA "Words" on Surfaces for DNA Computing," J. Am. Chem. Soc. 120:102777-10282 (1998).
Gross, C. A. et al, "Application of (3-Mercaptopropyl)trimethoxysilane as a Molecular Adhesive in the Fabrication of Vapor-Deposited Gold Electrodes on Glass Substrates," Anal. Chem. 63:85-88 (1991).
Jordon, C. E. et al, "Surface Plasmon Resonance Imaging Measurements of Electrostatic Biopolymer Adsorption onto Chemically Modified Gold Surfaces," Anal. Chem. 69:1449-1456 (1997).
Jordan, C. E. et al, "Surface Plasmon Resonance Imaging Measurements of DNA Hybridization Adsorption and Streptavidin/DNA Multilayer Formation at Chemically Modified Gold Surfaces," Anal. Chem. 69:4939-4947 (1997).
Knobloch, H. et al, "Dispersive Surface Plasmon Microscopy for the Characterization of Ultrathin Organic Films," Appl. Phys. Lett. 69:2336-2337 (1996).
Lideberg, B. et al, Surface Plasmon Resonance for Gas Detection and Biosensing, Sensors and Actuators, 4:299-304 (1983).
Pease, A. C. et al, "Light-Generated Oligonucleotide Arrays for Rapid DNA Sequence Analysis," Proc. Natl. Acad. Sci. 91:5022-5026 (1994).
Thiel, A. J., et al, "In Situ Surface Plasmon Resonance Imaging Detection of DNA Hybridization to Oligonucleotide Arrays on Gold Surfaces," Anal. Chem. 69:4948-4956 (1997).
Thomas, R. C. et al, "Probing Adhesion Forces at the Molecular Scale," J. Am. Chem. Soc. 117:3830-3834 (1995).
Winzeler, E. A. et al, "Direct Allelic Variation Scanning of the Yeast Genome," Science 281:1194-1197 (1998).
Zizlsperger, M. et al, "Multispot Parallel On-Line Monitoring of Interfacial Binding Reactions by Surface Plasmon Microscopy," Progr. Colloid. Polym. Sci. 109:244-253 (1998).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process to create biomolecule and/or cellular arrays on metal su does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process to create biomolecule and/or cellular arrays on metal su, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process to create biomolecule and/or cellular arrays on metal su will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-193884

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.