Process of screening plasma samples for effective antibody titer

Details Process of screening plasma samples for effective antibody titer Process of screening plasma samples for effective antibody titer

1995-01-27

1996-12-10

Nucker, Christine M.

Drug, bio-affecting and body treating compositions

Immunoglobulin, antiserum, antibody, or antibody fragment,...

Binds virus or component thereof

4241301, 5303894, 435 5, 435 79, 435 792, A61K 3942

Patent

active

055828272

ABSTRACT:
A process for identifying plasma samples containing effective antibody titers for the treatment and/or prophylaxis of infections caused by a respiratory virus. The process comprises contacting a plasma sample containing antibodies against a respiratory virus with the respiratory virus. The mixture of plasma sample and virus is then contacted with a plurality of cells. The remaining non-neutralized virus in the sample is then determined through an immunoassay following replication of the virus in the cells. Plasma samples which, at a preselected minimum antibody titer value, prevent viral replication in the cells, are then selected. Plasma from which the selected samples were derived are then pooled to provide an immunoglobulin preparation having increased effectiveness in the prophylaxis and/or treatment of infections caused by the respiratory virus.

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Anderson, et al., J. Clin. Microbiol., vol. 22, No. 6, pp. 1050-1052 (Dec. 1975).
Yolken, Rev. Infect. Dis., vol. 4, No. 1, pp. 35-59 (Jan.-Feb. 1982).
Tijssen, "Practice and Theory of Enzyme Immunoassays", Elsevier, New York, pp. 358-362 (1985).

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