Chemistry: natural resins or derivatives; peptides or proteins; – Proteins – i.e. – more than 100 amino acid residues – Separation or purification
Patent
1994-01-13
1995-04-18
Draper, Garnette D.
Chemistry: natural resins or derivatives; peptides or proteins;
Proteins, i.e., more than 100 amino acid residues
Separation or purification
530412, 530414, 530416, 530417, 530422, C07K 100, C07K 300, C07K 1500
Patent
active
054080410
ABSTRACT:
The present invention relates to the development of bone growth factors as therapeutics for the prevention and treatment of pathological conditions involving bone tissue. The present invention provides biologically active proteinaceous factors comprising polypeptides containing the amino acid sequence M-A-G-L-G-D-E-F-G-D, [SEQ ID NO: 1], (X) F E T L F G A/V E D V I/D A L Q F V C G D, [SEQ ID NO: 2], or A-Y-I-P-I-E-T-L-E-G-I/G-E-L-V-D/Q-T-G/L-Q-F, [SEQ ID NO: 3], or biologically active fragments or sequence analogues thereof. Among the biological properties of the proteinaceous materials of the present invention is the capability to promote the growth and/or differentiation of osteoblastic cells.
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Arnett Timothy R.
Burgess Wilson
Crumley Gregg R.
Garrett Ian R.
Gutierrez Gloria E.
Allen Marianne Porta
Draper Garnette D.
Goodman Rosanne
OsteoSA Inc.
Rhone-Poulenc Rorer Pharmaceuticals Inc.
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