Process of protecting a 1,2-aminoalcohol for reductive amination

Details Process of protecting a 1,2-aminoalcohol for reductive amination Process of protecting a 1,2-aminoalcohol for reductive amination

1996-04-05

1999-02-23

Shaver, Paul F.

Organic compounds -- part of the class 532-570 series

Organic compounds

Silicon containing

556410, 560190, 560196, 564374, 564382, C07F 710

Patent

active

058746013

ABSTRACT:
A process of protecting a 1,2- or 1,3-aminoalcohol for reductive amination coupling is provided. The alcohol is protected with trimethylsilyl chloride. Trimethylsilyl protected norepinephrine derivatives useful in the preparation of arbutamine are also provided.

REFERENCES:
patent: 5130468 (1992-07-01), Kempf
patent: 5486633 (1996-01-01), Pirrung et al.
patent: 5523442 (1996-06-01), Collard et al.
Pierce, Silylation of Organic Compounds, Rockford, IL, Jun. 1968, pp. 73-75, 81, and 476.
Iwase, H., et al., "Gas Chromatography-Mass Spectrometry of Trimethylsilyl Derivatives of Amines", Chem. Pharm. Bull., 27(4):1009-1014 (1979).
Greene, T. W., et al., "Protective groups in organic synthesis", John Wiley & Sons, New York, 68-73 & 406-414.

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