Process of producing ether-type thio-phospholipids

Details Process of producing ether-type thio-phospholipids Process of producing ether-type thio-phospholipids

1995-09-19

1997-09-02

Richter, Johann

Organic compounds -- part of the class 532-570 series

Organic compounds

Phosphorus esters

558169, 558194, 558183, 558 84, C07F 902

Patent

active

056634056

ABSTRACT:
A method of producing an ether-type thio-phospholipid of the formula (I): ##STR1## wherein: n is an integer of 13 to 17;

REFERENCES:
patent: 5221696 (1993-06-01), Ke et al.
patent: 5464754 (1995-11-01), Dennis et al.
Chemical Abstracts, vol. 121, No. 15, Oct. 10, 1994, Columbus Ohio, US; Abstract No. 180120, Achinami K. et al., "Preparation of ether-type thiophospholipids" *abstract* of JP-A-94 116 279 (Shino Test Corp; Japan), Apr. 26, 1994.
Chemical Abstracts, vol. 101, No. 11, Sep. 10, 1984, Columbus, Ohio, US; Abstract No. 090651, Muramatsu T. "Synthesis of thioether and thioester phospholipids" *abstract* of INSERM Symp. (INSSDM, 03780546); 83; vol. 23 (Platelet-Act. Factor Struct. Relat. Ether-Lipids); pp. 37-40, Tokyo Med. Dent. Univ.; Dep. Gen. Educ.; Ichikawa; 272; Japan (JP).
Tetrahedron Lett. (Teleay, 00404039); vol. 28 (16); pp. 1729-1732, California State Univ.; Dep. Chem.; Northridge; 91330, CA; USA (US); Bhatia S.K. et al., "Stereospecific synthesis of PAF analogs. Preparation of 1-hexadecyl-2-thioacetyl-2-deoxyglyceropho sphocholine (2-thioPAF)" p. 1730, formulas 6 and 1, (1987).
Anal. Biochem. (ANBCA2, 00032697); vol. 217 (1), pp. 25-32, Univ. California, San Diego; Dep. Chem.; La Jolla; 92093-0601; CA; USA (US), Reynolds L. J. et al., "1-Hexadecyl-2-arachidonoylthio-2-deoxy-sn-glycero-3-phosphorylcholine as a substrate for the microtiterplate assay of human cytosolic phospholipase A2" p. 27, formula 5 and paragraph: preparation of (5), (1994).
Chem. Pharm. Bull. (CPBTAL, 00092363); vol. 39 (5); pp. 1335-1336, Univ. Shizoka; Sch. Pharm. Sci.; Shizuoka; 422; Japan (JP), Murata M. et al., "New synthesis of 2-thio-PAF and related compounds as substrates of PAF acetylhydrolase and phospholipase A2", (1991).
Chem. Pharm. Bull. (CPBTAL, 00092363); vol. 40 (10); pp. 2849-2851, Univ. Shizuoka; Sch. Pharm. Sci., Shizuoka, 422; Japan (JP), Murata M. et al., "Synthesis of 2-thio-platlet activating factor and related compounds", (1992).
Stewart et al., J. Lipid Mediators (1991), 4(3), 299-308.
Bhatia et al., Synthesis (1989), 1, 16-20.
Bhatia et al., Tetrahedron Lett. (1987), 28(16), 1729-32.
Murata et al., Chem. harm. Bull. (1991), 39(5), 1335-6.

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