Process of producing 1-acyl-2-methyl-indolyl-3-alkanoic acids

Details Process of producing 1-acyl-2-methyl-indolyl-3-alkanoic acids Process of producing 1-acyl-2-methyl-indolyl-3-alkanoic acids

1975-07-24

1976-12-14

Gotts, Lewis

Chemistry of carbon compounds

Miscellaneous organic carbon compounds

C-metal

C07D20926, C07D20928

Patent

active

039975584

ABSTRACT:
The process is directed to the production of 1-acyl-2-methyl-indolyl-3-alkanoic acids having the general formula ##STR1## wherein R.sub.1 represents hydrogen, halogen, an alkoxy group or an aryloxy group, n is 1, 2 or 3, and R.sub.2 represents an aromatic group. A lactone having the general formula ##STR2## wherein R.sub.1 and n have the meanings stated above, is acylated by being reacted in a polar solvent in the presence of sodium hydride with an acid derivative having the general formula ##STR3## wherein R.sub.2 has the meaning stated above and X represents a halogen, to form a compound having a lactone ring and having the general formula ##STR4## wherein R.sub.1, R.sub.2, and n have the meanings stated above. The last-mentioned compound is hydrogenolyzed in the presence of a hydrogenation catalyst to open the lactone ring.

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