Process of preparing optically active allyl compound

Organic compounds -- part of the class 532-570 series – Organic compounds – Nitrogen attached directly or indirectly to the purine ring...

Reexamination Certificate

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Reexamination Certificate

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08076480

ABSTRACT:
Disclosed is a process of preparing an optically active allyl compound, e.g., as represented by formula (III):comprising asymmetrically coupling an allyl compound with an organic nucleophilic compound in the presence of a catalyst. The catalyst is preferably a transition metal complex compound having a phosphine ligand. The phosphine ligand is preferably a 2,3-bis(dialkylphosphino)pyrazine derivative. The pyrazine derivative is preferably a quinoxaline derivative. The transition metal is preferably palladium.

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patent: 1438227 (2003-08-01), None
patent: 2007-056007 (2007-03-01), None
Great Britain Office Action dated Dec. 19, 2008, issued in corresponding Great Britain Patent Application No. GB0813271.4.
Tsarev, Vasily N. et al.; “Novel Highly Efficient P-Chiral Ferrocenylimino Diamidophosphite Ligands for Pd-Catalysed Asymmetric Allylation”; European Journal of Organic Chemistry, vol. 10, pp. 2097-2105, 2005.
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Imamoto, Tsuneo et al.; “Highly enantioselective hydrosilylation of simple ketones catalyzed by rhodium complexes of P-chiral diphosphine ligands bearing tert-butylmethylphosphino groups”; Tetraedron: Asymmetry, vol. 17, 2006, pp. 560-565.
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