Process of preparing microcapsules of lactides or lactide copoly

Details Process of preparing microcapsules of lactides or lactide copoly Process of preparing microcapsules of lactides or lactide copoly

1985-04-11

1987-01-20

Lovering, Richard D.

Plastic and nonmetallic article shaping or treating: processes

Encapsulating normally liquid material

Liquid encapsulation utilizing an emulsion or dispersion to...

264 41, 424 19, 424 21, 424 35, 424DIG7, 4284022, 42840221, 514963, A61K 952, B01J 1302

Patent

active

046379053

ABSTRACT:
A process for preparing polylactide (PLA) microcapsules is described and involves dissolving PLA in a mixture of two miscible organic liquids, the higher vapor pressure liquid having solvent power for PLA and the second having little or no solvent power for PLA. The solution is prepared such that it is near its saturation point for PLA. Encapsulation of dispersed core material is achieved by vaporizing the liquid having solvent power for PLA causing phase separation of the PLA, then transferring the separated dispersion to an organic liquid having no solvent power for the PLA in order to harden the encapsulating coating. The disclosed process enables forming true microcapsules or reservoir-type devices encapsulating liquid core material particularly aqueous liquid core material and oil in water emulsion or suspensions.

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