Process of preparing imatinib and imatinib prepared thereby

Details Process of preparing imatinib and imatinib prepared thereby Process of preparing imatinib and imatinib prepared thereby

2004-01-08

2009-12-29

Wilson, James O (Department: 1624)

Organic compounds -- part of the class 532-570 series

Organic compounds

Nitrogen attached directly or indirectly to the purine ring...

C544S390000

Reexamination Certificate

active

07638627

ABSTRACT:
A process of preparing imatinib, either as the free base or as an acid addition salt, which process comprises reacting N-(2-methyl-5-aminophenyl-4-(3-pyridyl)-2-pyrimidine amine of formula (II) with a 4-(4-methyl-piperazino methyl)benzoyl halide of formula (III) in the presence of an inert organic solvent, so as to yield a hydrohalide salt of imatinib formula (I) where n represents 1, 2 or 3 and Hal represents bromo, chloro, fluoro or iodo, either in anhydrous or hydrated form, which can as desired optionally be further converted either to the free base or a further acid addition salt. The present invention is also concerned with imatinib prepared according to the above process.

REFERENCES:
patent: 5521184 (1996-05-01), Zimmermann
patent: 564 409 (1993-03-01), None
patent: 0 564 409 (1993-10-01), None
patent: WO 99/03854 (1999-01-01), None
Berge, et al., Pharmaceutical Salts, J. of Pharm. Sci., 66(1):1-19 (1977).
International Preliminary Examination Report dated Sep. 1, 2005.
International Search Report dated Sep. 1, 2004.

Affiliated with

Also associated with

Rating

Process of preparing imatinib and imatinib prepared thereby does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of preparing imatinib and imatinib prepared thereby, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of preparing imatinib and imatinib prepared thereby will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-4118813