Process of preparing genistein

Chemistry: molecular biology and microbiology – Micro-organism – tissue cell culture or enzyme using process... – Preparing heterocyclic carbon compound having only o – n – s,...

Patent

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

4352521, 435822, C12P 1706

Patent

active

055545190

ABSTRACT:
The present invention provides a process of preparing the isoflavone genistein. Genistein is prepared by fermenting the bacteria Saccharopolyspora erythraea in the presence of a soy-based substrate. A process of recovering genistein from a bacterial fermentation medium using alkaline, organic solvent extraction is also provided.

REFERENCES:
patent: 2653899 (1953-09-01), Bunch et al.
patent: 3974184 (1976-08-01), Umezawa et al.
patent: 4366248 (1982-12-01), Zienllik
patent: 4960908 (1990-10-01), Ito et al.
patent: 5070015 (1991-12-01), Petuch et al.
patent: 5124258 (1992-06-01), Arison et al.
patent: 5140042 (1992-08-01), Arison et al.
patent: 5141746 (1992-08-01), Fleury et al.
patent: 5141926 (1992-08-01), Weber et al.
patent: 5192671 (1993-03-01), Arison et al.
patent: 5320949 (1994-06-01), Shen
Akiyama, T., J. Ishida, S. Nakagawa, H. Ogawara, S. Watanabe, N. Itoh, M. Shibuya, and Y. Fukami. 1987. Genistein, A Specific Inhibitor Of Tyrosine-Specific Protein Kinases, J. Biol. Chem. 262, 5592-5595.
Akiyama, T., H. Ogawara. 1991. Use And Specificity Of Genistein As Inhibitor Of Protein Tyrosine Kinases. Methods Emzymol. 201:362-371.
Aoyagi, T.; T. Hazatok, M. Kumagai, M. Hamada, T. Takeuchi, H. Umezawa. 1975. Isoflavone Rhamunosides, Inhibitors of .beta.-Galactosidase Produced by Actinomycetes. J. Antibiot. 12:1006-1008.
Martin, P. W., K. B. Horowitz, D. S. Ryan, and W. L. McGurie. 1978. Phytoestrogen Inteaction With Estrogen Receptors In Human Breast Cancer Cells. Endocrinol. 103:1860-1867.
Messina, M. and S. Barnes. 1991. The Role Of Soy Products In Reducing The Risk Of Cancer. J. Natl. Cancer Inst. 83:541-545.
Nakayama, O.; M. Yagi, M. Tanaka, S. Kiyoto, I. Uchida, M. Hashimot, M. Okuhara, and M. Kohsaka. 1990. WS-7528, A New Isoflavanone With Estrogen Activity Isolated From Streptomyces Sp. No. 7528. The Journal of Antibiotics, 11:1394-1402.
Ogawara, H.; T. Akiyama, J. Ishida, S. Watanabe, and K. Suzuki. 1985. A Specific Inhibitor For Tyrosine Protein Kinase From Pseudomonas. J. Antibiot. 39:606-608.
Okura, A., H. Arakawa, H. Oka, T. Yoshinari, and Y. Monden. 1988. Effect Of Genistein On Topoisomerase Activity And On The Growth Of [VAL 12] Ha-ras-Transformed NIH 3T3 Cells. Biochem. Biophys. Res. Commun. 157:183-189.
Olah, A. F. and R. T. Sherwood. 1972. Glycosidase Activity and Flavonoid Accumulation in Alfalfa Infected by Aschochyta Imperfecta. Phytopathology 63:739-742.
Perez-Pons J. A.; A. Cayetano, X. Rebordosa, J. Lloberas, A. Guasch, E. Querol. 1994. A Beta-Glucosidase Gene (Bgl3) From Streptomyces Sp. Strain QM-B814. Molecular Cloning, Nucleotide Sequence, Purification And Characterization Of The Encoded Enzyme, A New Member Of Family 1 Glycosyl Hhydrolases. Eur. J. Biochem. 223:557-565.
Sarlaslani, F. S.; and D. A. Kunz, 1986. Induction Of Cytochrome P-450 In Streptomyces Griseus. Biochemical and Biophysical Research Communications, 141, 2:405-410.
Schliemann, W. .beta.-D-Glucosidasen (EC 3.2.1.21) der Mikroorganismen. Die Pharmazie. 1983. 38:287-303.
Uckun, F. M., W. E. Evans, C. J. Forsyth, K. G. Waddick, L. T. Ahlgren, L. M. Chelstrom, A. Burkhardt, J. Bolen, and D. E. Myers. 1995. Biotherapy Of B-Cell Precursor Leukemia By Targeting Genistein To CD19-Associated Tyrosine Kinases. Science 267:886-891.
Walter, E. D. 1941. Genistin (An Isoflavone Glucoside) And Its Aglucone, Genistein, From Soybeans. 63: 3273-3275.
Wright, R. M.; M. D. Yablonsky, Z. P. Shalita, A. K. Goyal, and D. E. Eveleigh. 1992. Cloning Characterization, And Nucleoside Sequence Of A Gene Encoding Microbispora Bispora BglB, A Thermostable Beta-Glucosidase Expressed In Escherichia Coli. Appl. Environ. Microbiol. 58:3455-3465.
Yam, L. T., C. Y. Li, and W. H. Crosby. 1971. Cytochemical Identification Of Monocytes And Granulocytes. Am. J. Clin. Pathol. 55:283-290.
Baker, W. and R. Robinson, 1928. Synthetical Experiments in the IsoFlavone Group. Part III. A synthesis of Genistein.
Castle, L. A.; K. D. Smith, and R. O. Morris. 1992. Cloning And Sequencing Of An Agrobacterium Tumefaciens .beta.-Glucosidase Gene Involved In Modifying A Vir-Inducing Plant Signal Molecule. Journal of Bacteriology, 5:1478-1486.
Chimura, H. T. Sawa, Y. Kumada, H. Naganawa, M. Matsuzaki, T. Takia, M. Hamada. T. Takeuchi, and H. Umezawa. 1975. New Isoflavones, Inhibiting Catechol-O-Methyltransferase, Produced By Streptomyces. J. Antibiot. 28:619-626.
Collins, S. J., A. Bonder, R. Ting. and R. C. Gallo. 1980. Induction Of Morphological And Functional Differentiation Of Human Promyelocytic Leukemia Cells (HL-60) By Components Which Induce Differentiation Of Murine Leukemia Cells. Int. J. Cancer 25:213-218.
Constantinou, A., K. Kiguchi, and E. Huberman. 1990. Induction Of Differentitaion And DNA Strand Breakage In Human HL-60 And K-562 Leukemia Cells By Genistein. Cancer Res. 50:2618-2624.
Constantionou, A., and E. Huberman. 1995. Genistein As An Inducer Of Tumor Cell Differentiation: Possible Mechanism Of Action. Proc. Soc. Exper. Biol. Med. 208:109-115.
Constantinou, A., R. G. Mehta, C. Rao, K. V. N. Vaughn, and R. C. Moon. 1995. Plant Flavonoids As DNA Topoisomerase Antagonists And Poisons: Structure-Activity Relationships. J. Natural Products 58:217-225.
Funayama, S. Y. Anraku, A. Mita, K. Komiyama, and S. Omura. 1989. Structural Study Of Isoflavonoids Possessing Antioxidant Activity Isolated From The Fermentation Broth Of Streptomyces Sp. J. Antibiot. 42:1350-1355.
Gamba-Vitalo, C., O. C. Blair, S. R. Keyes, and A. C. Sartorelli. 1986. Differentiation Of WEHI-3B D.sup.+ Monomyelocytic Leukemia Cells By Retinoic Acid And Aclacinomycin A. Cancer Res. 46:1189-1194.
Ganguly, A. K. and O. Z. Sarre. 1970. Genistein And Daidzein, Metabolities Of Micromonospora Halophytica. Chemistry and Industry (Feb.) p. 201.
Grisebach, H. 1967. Biosynthesis Of Flavonoids And Related Products. In Biosynthetic Patterns in Microorganisms and Higher Plants (Author, H. Grisebach). John Wiley and Sons, Inc., New York. pp. 1-31.
Hazato, T., H. Naganawa, M. Kumagai, T. Aoyagi, and H. Umezawa. 1979. .beta.-Galactosidase-Inhibiting New Isoflavnoids Produced by Actinomycetes. J. Antibiot. 32:217-222.
Hay, G. W.; D. W. S. Westlake, and F. J. Simpson. 1961. Degradation of Rutin by Aspergillus Flavus. Purification and Characterization of Rutinase. Can. J. Microbiol. 7:921-932.
Hudson, A. T. and R. Bentley. 1969. The Isolation Of Isoflavorable From Bacteria. Chemical Communications, (J. Chem. Soc. -D). pp. 830-831.
Kiguchi, K., A. I. Constantinou, and E. Huberman. 1990. Genisten-Induced Cell Differentiation And Protein Linked DNA Strand Breakage In Human Melanoma Cells. Cancer Communications 2:271-278.
Komiyama, Kanki; S. Funayama, Y. Anraku, A. Mita, Y. Takahashi, and S. Omura. 1989. Isolation Of Isoflavonoids Possessing Antioxidant Activity Isolated From The Fermentation Broth Of Streptomyces Sp. J. Antibiotic 42:1344-1349.
Kondo, H.; S. Nakajima N. Yamamoto. A. Okura, F. Satoh. H. Suda, M. Okanishi, and N. Tanaka. 1990. BE-14348 Substances, New Specific Estrogen-Receptor Binding Inhibitors. Production, Isolation, Structure Determination, And Biological Properties. J. Antibiotics 43:1533-1542.
MacDonald, I. A.; R. G. Bussard, D. M. Hutshison, and L. V. Holdeman. 1984. Rutin-Induced .beta.-Glucosidase Activity in Streptococcus Faecium VGH-1 and Streptococcus sp. Strain FRP-17 Isolated From Human Feces: Formation Of The Mutagen, Quercetin, From Rutin. Applied and Environmental Microbiology, 47:350355.
Markovits, J. C. Linassier, P. Fosse, J. Couprie, J. Pierre, A. Jacquemin-Sablon, J. M. Saucier, J. B. LePecq. A. K. Larsen. 1989. Inhibitory Effects Of The Tyrosine Kinase Inhibitor Genistein On Mammalian DNA Topoisomerase II. Cancer Res. 9:5111-5117.

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process of preparing genistein does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of preparing genistein, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of preparing genistein will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-1319883

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.