Process of preparing cephalosporanic acid ester derivatives

Details Process of preparing cephalosporanic acid ester derivatives Process of preparing cephalosporanic acid ester derivatives

1977-03-09

1979-01-30

Rollins, Alton D.

Organic compounds -- part of the class 532-570 series

Organic compounds

Chalcogen in the nitrogen containing substituent

424246, 544 30, 542420, C07D50104

Patent

active

041374070

ABSTRACT:
A process of preparing a .DELTA..sup.3 -cephalosporanic acid ester derivative which comprises reacting a cephalosporanic acid sulfoxide ester derivative with thionyl halide or a phosphorous halide.
The compounds prepared by the process of this invention are useful as intermediate compounds for preparing cephalosporin antibiotics and the compounds themselves are also potential antibacterials.

REFERENCES:
kukolja et al., J. Am. Chem. Soc., vol. 94, pp. 7169-7170, (1972).
Morrison et al., Organic Chemistry, (New York, 1966), pp. 155, 470-473, 727, 732.
Wagner et al., Synthetic Organic Chemistry, (New York, 1953), pp. 32-38.

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