Process of preparing captopril

Details Process of preparing captopril Process of preparing captopril

1990-11-05

1992-03-17

Raymond, Richard L.

Organic compounds -- part of the class 532-570 series

Organic compounds

Heterocyclic carbon compounds containing a hetero ring...

562401, C07D20716

Patent

active

050970437

ABSTRACT:
An optically active amine compound and a method for preparing same are provided which compound has the structure ##STR1## in the form of its R-(+) enantiomer or S-(-) enantiomer, wherein R and R.sup.1 are independently H, lower alkyl or halogen, R.sup.2 is H or lower alkyl and R.sup.3 is lower alkyl, the optically active amine is useful in the optical resolution of DL-3-acylthio-2-methylpropanoic acid wherein acyl is acetyl or benzoyl. The optically active D-(+)-3-acylthio-2-methylpropanoic acids are used as intermediates for preparing antihypertensive agents, such as captopril.

REFERENCES:
patent: 4346045 (1982-08-01), De Heij
patent: 4585595 (1986-04-01), Houbiers
patent: 5001251 (1991-03-01), MacManus

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