Process of preparation of olanzapine form I

Organic compounds -- part of the class 532-570 series – Organic compounds – Unsubstituted hydrocarbyl chain between the ring and the -c-...

Reexamination Certificate

Rate now

  [ 0.00 ] – not rated yet Voters 0   Comments 0

Details

C514S220000

Reexamination Certificate

active

10449643

ABSTRACT:
A process for the preparation of polymorph Form I of 2-methyl-4-(4-methyl-1-piperazinyl)-10H-thieno[2,3-b][1,5] benzodiazepine, or olanzapine.

REFERENCES:
patent: 3985750 (1976-10-01), Protiva et al.
patent: 4115568 (1978-09-01), Chakrabarti et al.
patent: 4115574 (1978-09-01), Chakrabarti et al.
patent: 5229382 (1993-07-01), Chakrabarti et al.
patent: 5605897 (1997-02-01), Beasley, Jr. et al.
patent: 5627178 (1997-05-01), Chakrabarti et al.
patent: 5631250 (1997-05-01), Bunnell et al.
patent: 5637584 (1997-06-01), Larsen
patent: 5703232 (1997-12-01), Bunnell et al.
patent: 5736541 (1998-04-01), Bunnell et al.
patent: 5817655 (1998-10-01), Chakrabarti et al.
patent: 5817656 (1998-10-01), Beasley, Jr. et al.
patent: 5817657 (1998-10-01), Beasley, Jr. et al.
patent: 6008216 (1999-12-01), Chakrabarti et al.
patent: 6020487 (2000-02-01), Bunnell et al.
patent: 6251895 (2001-06-01), Larsen et al.
patent: 6348458 (2002-02-01), Hamied et al.
patent: 2002/0086993 (2002-07-01), Davies et al.
patent: 2002/0165225 (2002-11-01), Hamied et al.
patent: 2005/0239772 (2005-10-01), Piechaczek et al.
patent: 0 454 436 (1991-10-01), None
patent: 0 733 367 (1996-09-01), None
patent: 0 733 634 (1996-09-01), None
patent: 0 733 635 (1996-09-01), None
patent: 0 831 098 (1998-03-01), None
patent: 0 911 028 (1998-09-01), None
patent: 0 733 634 (2000-11-01), None
patent: 1 095 941 (2001-05-01), None
patent: 1 155 696 (2001-11-01), None
patent: 0 831 097 (2002-07-01), None
patent: WO 96/30374 (1996-10-01), None
patent: WO 02/18390 (2001-03-01), None
patent: WO 01/47933 (2001-07-01), None
patent: WO 02/060906 (2002-08-01), None
patent: WO 03/037903 (2003-05-01), None
patent: WO 03097650 (2003-05-01), None
patent: WO 03/055438 (2003-07-01), None
Chakrabarti et al., “10-Piperazinyl-4H-thieno[3,2-b][1,5]- and -[3,4-b][1,5]benzodiazepines as Potential Neuroleptics,” J. Med. Chem., vol. 23, pp. 884-889 (1980).
Chakrabarti et al., “4-Piperazinyl-10H-thieno[2,3-b][1,5]benzodiazepines as Potential Neuroleptics,” J. Med. Chem., vol. 23, pp. 878-884 (1980).
Chakrabarti et al., “Heteroarene-fused Benzodiazepines. Part 1. Synthesis of Thieno-[2,3-b] [1,5]-, -[3,2-b] [1,5]-, and -[3,4-b][1,5]-benzodiazepinones,” J. C. S. Perkin I, pp. 937-941 (1978).
Campiani et al., “New Antipsychotic Agents with Serotonin and Dopamine Antagonist Properties Based on a Pyrrolo[2,1-b][1,3]benzothiazepine Structure”,J Med Chem, vol. 41, No. 20, pp. 3763-3772 (1998).
Mouithys-Mickalad et al., “Electrooxidation Potential as a Tool in the Early Screening for New Safer Clozapine-like Analogues”,J Med Chem, vol. 44, No. 5, pp. 769-776 (2001).
Piper et al., “10-Propargylaminopterin and Alkyl Homologues of Methotrexate as Inhibitors of Folate Metabolism”,J Med Chem, vol. 25, pp. 877-880 (1982).
Press et al., “10-(Alkylamino)-4H-thieno[3,4-b][1,5]benzodiazepines. A Novel Class of Potential Neuroleptic Agents”,J Med Chem, vol. 22, No. 6, pp. 725-731 (1979).

LandOfFree

Say what you really think

Search LandOfFree.com for the USA inventors and patents. Rate them and share your experience with other people.

Rating

Process of preparation of olanzapine form I does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Process of preparation of olanzapine form I, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Process of preparation of olanzapine form I will most certainly appreciate the feedback.

Rate now

     

Profile ID: LFUS-PAI-O-3845414

  Search
All data on this website is collected from public sources. Our data reflects the most accurate information available at the time of publication.